Respirology. 2004 Mar;9(1):38-42. Links
The effects of antioxidants on exercise-induced lipid peroxidation in patients with COPD.
Agacdiken A, Basyigit I, Ozden M, Yildiz F, Ural D, Maral H, Boyaci H, Ilgazli A, Komsuoglu B.
Department of Cardiology, University Faculty of Medicine, Kocaeli, Turkey.
The effects of antioxidants on exercise-induced lipid peroxidation in patients with COPD AGACDIKEN
A, BASYIGIT I, OZDEN M, YILDIZ F, URAL D, MARAL H, BOYACI H, ILGAZLI A, KOMSUOGLU B. Respirology
2004; 9: 38-42Objective: The oxidant-antioxidant balance plays an important role in the pathogenesis
of COPD. The aim of the present study was to evaluate the effects of exercise, as an oxidative
stress factor on the oxidant-antioxidant balance and to investigate whether short-term antioxidant
treatment affects lipid peroxidation products. Methodology: Twenty-one stable COPD patients and 10
control subjects were included in the study. Symptom-limited exercise tests were performed by all
subjects. Blood was collected before and 1 h after exercise in control subjects and before, 1 and 3
h after exercise in COPD patients, for analysis of malondialdehyde (MDA), reduced glutathione (GSH)
and vitamin E (VE) levels. VE and vitamin C treatments were added to the regular bronchodilator
therapy in 10 COPD patients for 1 month. After the treatment period, an exercise test was performed
and blood was collected again for MDA, GSH and VE levels. Results: Baseline GSH and VE levels were
significantly lower in the COPD group when compared with the control subjects. There was no
statistically significant difference in MDA levels between the two groups. In the COPD group, MDA
levels 3 h after exercise were significantly higher than at baseline. In contrast there were no
significant differences in MDA, VE and GSH levels in the control group after exercise. VE and MDA
levels increased significantly after exercise in COPD patients but there was no difference in GSH
levels. Baseline exercise time was significantly lower in the COPD group than in the controls. In 10
COPD patients who were given antioxidant therapy, their exercise time increased significantly and
there was no increase in MDA and VE levels after the repeated exercise test. Conclusions:
Antioxidant levels were significantly lower in COPD patients than in control subjects. In these
patients, exercise results in more significant oxidative stress and lipid peroxidation than in
control subjects and antioxidant therapy may decrease lipid peroxidation following exercise and
improve exercise capacity.
PMID: 14982600 [PubMed - in process]
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