Insulin Resistance

"Sleepyman" <[email hidden]> wrote in message
"]news:[email hidden]...

Quoted message said:

Wondering about Insulin Resistance. As I know there

is no specific insulin

Quoted message said:

resistance test, do we know if it is a semi-constant

level, that can be

Quoted message said:

brought down slowly, or is it more similar to Bg

levels, in that it can

Quoted message said:

change rapidly?

Insulin resistance is tied in with fat. The more fat tissue you have the more likely you are to have
insulin resistance. It wouldn't change rapidly, even with dieting, as it takes a while for someone
to go from obesity to normal weight levels (or making more muscle and reducing the fat tissue).
Reducing insulin resistance can happen with diet alone but most doctors prefer to give an insulin
resistance drug to type 2's like Metformin as well as advise weight loss. Building muscle mass is a
big help also.

Insulin resistance does not mean a type 2 can't control their diabetes. Many obese type 2's control
with very low carb. But losing the fat tissue and gaining muscle would help enormously, allow a bit
more leeway re the amount of carbs a type 2 could eat every meal. Not all overweight, underexercised
people progress to diabetes, there is still a genetic pre disposition (unless there has been a
breakthrough I haven't heard about).

So in a nutshell, keep weight close to normal and keep active (building muscle helps) and you may
never get insulin resistance or if you have it already you can control the type 2 much easier.

Sleepyman <[email hidden]> wrote in
:"]news:[email hidden]:

Quoted message said:

Wondering about Insulin Resistance. As I know there is no specific insulin resistance test, do we
know if it is a semi-constant level, that can be brought down slowly, or is it more similar to Bg
levels, in that it can change rapidly?

There are actually a couple of methods for measuring insulin resistance, but they are usually
reserved for research settings.

As there are a number of mechanisms that cause insulin resistance, some understood fairly well
and some not at all well, and there are a number of time scales involved. Some are reversible
and some not.

Three of the most common mechanisms for increasing insulin resistance are aging, weight gain, and
sedentary life style. While these aspects are clearly related, it appears that they function to some
degree independently.

It is, of course, fairly difficult to do much about aging. Removing excess weight, or more properly
body fat ratio, seems to have a range of difficulty in the population. None-the-less it is clear
that reducing excess weight will reduce insulin resistance. Sometimes a relatively small weight loss
will produce noticeable results. The time scale is, naturally, the time scale of the weight loss.

Exercise effects insulin resistance on several time scales. There is an immediate effect during
exercise as insulin independent glucose disposal pathways are opened up. As exercise becomes
regular, other insulin resistance reductions appear and persist for various periods from a few days
to a few weeks. It may take a few days to a few weeks to begin to see these results.

Sleepyman wrote in message <[email hidden]>...

Quoted message said:

Wondering about Insulin Resistance. As I know there is no specific insulin resistance test, do we
know if it is a semi-constant level, that can be brought down slowly, or is it more similar to Bg
levels, in that it can change rapidly?

Sleepy

There are a variety of Insulin Resistance Tests. Some are reserved for the Research Docs only

(e.g. Euglycemic Insulin Clamp or Frequently Sampled Intravenous Glucose Tolerance Test (FSIVGTT)

One test which your doc can run is the HOMA-R test. One measures fasting blood sugar and fasting
insulin level simultaneously.

The product of the the values is a measure of Insulin Resistance.

Much, much, more than a normal person would want to know about HOMA can be found at:

medforum.nlvascular dysfunction precedes .htmOpen ↗

care.diabetesjournals.org449.pdfOpen ↗

The QUICKI test is mathematically equivalent to the HOMA test

Of course, that measures your Insulin Resistance "that morning"

I find that heavy exercise can affect my insulin injection requirements for 24 hours. Since I am
chubby ( let us avoid the "O" word) I presume that I am tracking effects on exercise on Insulin
Resistance.

High blood sugars can (will??) produce temporary Insulin Resistance.

Regards
Old Al

One rule of thumb is the ratio of lipid blood values. In particular the ratio of trig / hdl, where a
value of < 3 is taken as a good measure of resistence.

Quoted message said:

Wondering about Insulin Resistance. As I know there is no specific insulin resistance test, do we
know if it is a semi-constant level, that can be brought down slowly, or is it more similar to Bg
levels, in that it can change rapidly?

Sleepy

-----------------
Eskimo/Inuit up!
-----------------
T2- 3/14/01

In article <[email hidden]>,

Quoted message said:

One rule of thumb is the ratio of lipid blood values. In particular the ratio of trig / hdl, where
a value of < 3 is taken as a good measure of resistence.

You sure that's not greater than 3 rather than less than 3? A tri/HDL ratio of less than or equal to
2.0 is ideal.

Priscilla

In article <[email hidden]>,

Quoted message said:

One rule of thumb is the ratio of lipid blood values. In particular the ratio of trig / hdl, where
a value of < 3 is taken as a good measure of resistence.

This seems strange, as high triglycerides are considered bad and high HDL is considered good.
--
This address is for information only. I do not claim that these views are those of the Statistics
Department or of Purdue University. Herman Rubin, Department of Statistics, Purdue University
[email hidden] Phone: (765)494-6054 FAX: (765)494-0558

Priscilla Ballou wrote in message ...

Quoted message said:

In article said:

One rule of thumb is the ratio of lipid blood values. In particular the ratio of trig / hdl,
where a value of < 3 is taken as a good measure of resistence.

You sure that's not greater than 3 rather than less than 3? A tri/HDL ratio of less than or equal
to 2.0 is ideal.

Priscilla

That one came up a while back. The 3.0 is a conservative estimate of "too high"; it identifies
the abnormal conditions brought about by elevated Insulin Resistance.

When you think about it, a conservative estimate of abnormal really shouldn't be that close to
"ideal" lest you end up with a slew of false negatives.

Regards
Old Al

Herman Rubin said:

In article said:

One rule of thumb is the ratio of lipid blood values. In particular the ratio of trig / hdl, where
a value of < 3 is taken as a good measure of resistence.

This seems strange, as high triglycerides are considered bad and high HDL is considered good.

The lower the ratio the better;

TG 200/ HDL 35 ration is 6; these are common diabetic values.

TC 100/ HDL 50 ration is 2; these are cited as target values

--
K'neH'a'Iw

Uncloaking, Shields up.

I don't follow your question. The info I have seen is < 3, which is also what = to or < 2 would
encompass. That number is using the US unit of measure, the number outside of the US is indeed a
lower number for that measureing scale.

Quoted message said:

One rule of thumb is the ratio of lipid blood values. In particular the ratio of trig / hdl, where
a value of < 3 is taken as a good measure of resistence.

You sure that's not greater than 3 rather than less than 3? A tri/HDL ratio of less than or equal to
2.0 is ideal.

You are correct, but in those with high insulin resistence the ratio is over 3, trig and hdl are not
directly related. A trig of 300 and hdl of 50 has a ratio of 6. The numbers above are not unusual in
a diabetic where trigs often sore even with a good hdl; such as the 50 in the example. High
resistence leads to high trigs, which can in time lead to poor hdl numbers also, the trigs don't
directly create the hdl level.

Quoted message said:

One rule of thumb is the ratio of lipid blood values. In particular the ratio of trig / hdl, where
a value of < 3 is taken as a good measure of resistence.

This seems strange, as high triglycerides are considered bad and high HDL is considered good.

[email hidden] quoth:

Quoted message said:

I don't follow your question. The info I have seen is < 3, which is also what = to or < 2 would
encompass.

No, =< 2 would be included in <3. It wouldn't encompass it. (The smaller cannot encompass
the larger.)

Quoted message said:

That number is using the US unit of measure, the number outside of the US is indeed a lower number
for that measureing scale.

I think the confusion is in the way you worded it.

You said that less than 3 was "a good measure of resistence." Do you mean that it's a good value in
terms of resistence, or it's an effective measure of resistence? I read it as the latter, which
seems backwards to me. A higher value would indicate greater resistence. 3 is a lower value and
would not be so clearly indicating resistence.

Quoted message said:

Quoted message said:

One rule of thumb is the ratio of lipid blood values. In particular the ratio of trig / hdl,
where a value of < 3 is taken as a good measure of resistence.

Quoted message said:

You sure that's not greater than 3 rather than less than 3? A tri/HDL ratio of less than or equal
to 2.0 is ideal.

Priscilla

In article <[email hidden]>,

K'neH'a'Iw said:

Herman Rubin wrote:

Quoted message said:

Quoted message said:

In article <[email hidden]>, <[email hidden]> wrote:

Quoted message said:

Quoted message said:

Quoted message said:

One rule of thumb is the ratio of lipid blood values. In particular the ratio of trig / hdl,
where a value of < 3 is taken as a good measure of resistence.

Quoted message said:

Quoted message said:

This seems strange, as high triglycerides are considered bad and high HDL is considered good.

Quoted message said:

The lower the ratio the better;

Quoted message said:

TG 200/ HDL 35 ration is 6; these are common diabetic values.

Quoted message said:

TC 100/ HDL 50 ration is 2; these are cited as target values

I definitely have insulin resistance. However, my last ratio was TG 80 / HDL 85. My previous ones
were not that good, but were still less than 2.
--
This address is for information only. I do not claim that these views are those of the Statistics
Department or of Purdue University. Herman Rubin, Department of Statistics, Purdue University
[email hidden] Phone: (765)494-6054 FAX: (765)494-0558

Herman Rubin said:

Quoted message said:

The lower the ratio the better;

Quoted message said:

TG 200/ HDL 35 ration is 6; these are common diabetic values.

Quoted message said:

TC 100/ HDL 50 ration is 2; these are cited as target values

I definitely have insulin resistance. However, my last ratio was TG 80 / HDL 85. My previous ones
were not that good, but were still less than 2.

Mine are in that same range, but I don't know if I am insulin resistant or not. I assume I am
because I am T2.

--
K'neH'a'Iw

Uncloaking, Shields up.