General fitness, health and nutrition · Public discussion

airway obstruction / ascorbate

Doe · 2004-01-17T19:03:00+00:00

Am J Vet Res. 2004 Jan; 65(1): 80-7. Related Articles, Links Pulmonary epithelial lining fluid and plasma ascorbic acid concentrations in horses affected by recurrent airway obstruction. Deaton CM, Marlin DJ, Smith NC, Harris PA, Roberts CA, Schroter RC, Kelly FJ. Centre for Equine Studies, Animal Health Trust, Lanwades Park, Kentford, Suffolk, CB8 7UU, UK. OBJECTIVE: To determine the pulmonary epithelial lining fluid (ELF) concentrations and degree of oxidation of ascorbic acid in horses affected by recurrent airway obstruction (RAO) in the presence and absence of neutrophilic airway inflammation. ANIMALS: 6 RAO-affected horses and 8 healthy control horses. PROCEDURE: Nonenzymatic antioxidant concentrations were determined in RBC, plasma, and ELF samples of control horses and RAO-affected horses in the presence and absence of airway inflammation. RESULTS: ELF ascorbic acid concentration was decreased in RAO-affected horses with airway inflammation (median, 0.06 mmol/L; 25th and 75th percentiles, 0.0 and 0.4 mmol/L), compared with RAO-affected horses without airway inflammation (1.0 mmol/L; 0.7 and 1.5 mmol/L) and control horses (2.2 mmol/L; 1.4 and 2.2 mmol/L). Epithelial lining fluid ascorbic acid remained significantly lower in RAO-affected horses without airway inflammation than in control horses. Moreover, the ELF ascorbic acid redox ratio (ie, ratio of the concentrations of dehydroascorbate to total ascorbic acid) was higher in RAO-affected horses with airway inflammation (median, 0.85; 25th and 75th percentiles, 0.25 and 1.00), compared with RAO-affected horses without airway inflammation (0.04; 0.02 and 0.22). The number of neutrophils in bronchoalveolar lavage fluid was inversely related to the ELF ascorbic acid concentration (r = -0.81) and positively correlated with the ascorbic acid redox ratio (r = 0.65). CONCLUSIONS AND CLINICAL RELEVANCE: Neutrophilic inflammation in horses affected by RAO is associated with a reduction in the ELF ascorbic acid pool. Nutritional supplementation with ascorbic acid derivatives in horses affected by RAO is an area for further investigation. PMID: 14719707 [PubMed - in process] -------------------------------------------------------------------------- ------ Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

Started by Doe · 17 January 2004 · Last activity 18 January 2004 · 3 posts · 330 views

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Original section: General fitness, health and nutrition
Published: 17 January 2004
Last activity: 18 January 2004
Original author: Doe
Posts: 3
Discussion status: Public discussion
Total views: 330
Views / 30 days: 0
Topics: Nutrition

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Original post
Doe
Archived post

17 January 2004, 19:03 UTC #1

Am J Vet Res. 2004 Jan; 65(1): 80-7. Related Articles, Links
Pulmonary epithelial lining fluid and plasma ascorbic acid concentrations in horses affected by
recurrent airway obstruction.
Deaton CM, Marlin DJ, Smith NC, Harris PA, Roberts CA, Schroter RC, Kelly FJ.
Centre for Equine Studies, Animal Health Trust, Lanwades Park, Kentford, Suffolk, CB8 7UU, UK.
OBJECTIVE: To determine the pulmonary epithelial lining fluid (ELF) concentrations and degree of
oxidation of ascorbic acid in horses affected by recurrent airway obstruction (RAO) in the presence
and absence of neutrophilic airway inflammation. ANIMALS: 6 RAO-affected horses and 8 healthy
control horses. PROCEDURE: Nonenzymatic antioxidant concentrations were determined in RBC, plasma,
and ELF samples of control horses and RAO-affected horses in the presence and absence of airway
inflammation. RESULTS: ELF ascorbic acid concentration was decreased in RAO-affected horses with
airway inflammation (median, 0.06 mmol/L; 25th and 75th percentiles, 0.0 and 0.4 mmol/L), compared
with RAO-affected horses without airway inflammation (1.0 mmol/L; 0.7 and 1.5 mmol/L) and control
horses (2.2 mmol/L; 1.4 and 2.2 mmol/L). Epithelial lining fluid ascorbic acid remained
significantly lower in RAO-affected horses without airway inflammation than in control horses.
Moreover, the ELF ascorbic acid redox ratio (ie, ratio of the concentrations of dehydroascorbate to
total ascorbic acid) was higher in RAO-affected horses with airway inflammation (median, 0.85; 25th
and 75th percentiles, 0.25 and 1.00), compared with RAO-affected horses without airway inflammation
(0.04; 0.02 and 0.22). The number of neutrophils in bronchoalveolar lavage fluid was inversely
related to the ELF ascorbic acid concentration (r = -0.81) and positively correlated with the
ascorbic acid redox ratio (r = 0.65). CONCLUSIONS AND CLINICAL RELEVANCE: Neutrophilic inflammation
in horses affected by RAO is associated with a reduction in the ELF ascorbic acid pool. Nutritional
supplementation with ascorbic acid derivatives in horses affected by RAO is an area for further
investigation.
PMID: 14719707 [PubMed - in process]
--------------------------------------------------------------------------
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Who loves ya. Tom Jesus Was A Vegetarian! jesuswasavegetarian.7h.comjesuswasavegetarian.7h.com Man Is A Herbivore!
pages.ivillage.commanisaherbivore DEAD PEOPLE WALKING
pages.ivillage.comdeadpeoplewalking

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Cj
Archived post

18 January 2004, 01:04 UTC #2

[email hidden] (doe) wrote in message news:<[email hidden]>...
Quoted message said:
Am J Vet Res. 2004 Jan; 65(1): 80-7. Related Articles, Links
Pulmonary epithelial lining fluid and plasma ascorbic acid concentrations in horses affected by
recurrent airway obstruction.
your point is?

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Anth
Archived post

18 January 2004, 02:02 UTC #3

Substantial ascorbate is shown to prevent damage pulmonary epithelial also in humans. Don't have the
study handy - as I recall it's on the vitamin c foundation site. This is good news if you are smoker
or suffer health hazards because of a smoker. Anth
"doe" <[email hidden]> wrote in message "]news:[email hidden]...
Quoted message said:
Am J Vet Res. 2004 Jan; 65(1): 80-7. Related Articles, Links
Pulmonary epithelial lining fluid and plasma ascorbic acid concentrations

in
Quoted message said:
horses affected by recurrent airway obstruction.
Deaton CM, Marlin DJ, Smith NC, Harris PA, Roberts CA, Schroter RC, Kelly

FJ.
Quoted message said:

Centre for Equine Studies, Animal Health Trust, Lanwades Park, Kentford, Suffolk, CB8 7UU, UK.
OBJECTIVE: To determine the pulmonary epithelial lining fluid (ELF) concentrations and degree of
oxidation of ascorbic acid in horses affected

by
Quoted message said:
recurrent airway obstruction (RAO) in the presence and absence of

neutrophilic
Quoted message said:
airway inflammation. ANIMALS: 6 RAO-affected horses and 8 healthy control horses. PROCEDURE:
Nonenzymatic antioxidant concentrations were determined

in
Quoted message said:
RBC, plasma, and ELF samples of control horses and RAO-affected horses in

the
Quoted message said:
presence and absence of airway inflammation. RESULTS: ELF ascorbic acid concentration was
decreased in RAO-affected horses with airway

inflammation
Quoted message said:
(median, 0.06 mmol/L; 25th and 75th percentiles, 0.0 and 0.4 mmol/L),

compared
Quoted message said:
with RAO-affected horses without airway inflammation (1.0 mmol/L; 0.7 and

1.5
Quoted message said:
mmol/L) and control horses (2.2 mmol/L; 1.4 and 2.2 mmol/L). Epithelial

lining
Quoted message said:
fluid ascorbic acid remained significantly lower in RAO-affected horses

without
Quoted message said:
airway inflammation than in control horses. Moreover, the ELF ascorbic

acid
Quoted message said:
redox ratio (ie, ratio of the concentrations of dehydroascorbate to total ascorbic acid) was
higher in RAO-affected horses with airway inflammation (median, 0.85; 25th and 75th percentiles,
0.25 and 1.00), compared with RAO-affected horses without airway inflammation (0.04; 0.02 and
0.22). The number of neutrophils in bronchoalveolar lavage fluid was inversely

related to
Quoted message said:
the ELF ascorbic acid concentration (r = -0.81) and positively correlated

with
Quoted message said:
the ascorbic acid redox ratio (r = 0.65). CONCLUSIONS AND CLINICAL

RELEVANCE:
Quoted message said:
Neutrophilic inflammation in horses affected by RAO is associated with a reduction in the ELF
ascorbic acid pool. Nutritional supplementation with ascorbic acid derivatives in horses affected
by RAO is an area for further investigation.
PMID: 14719707 [PubMed - in process]
--------------------------------------------------------------------------
------
Who loves ya. Tom Jesus Was A Vegetarian! jesuswasavegetarian.7h.comjesuswasavegetarian.7h.com Man Is A Herbivore!
pages.ivillage.commanisaherbivore DEAD PEOPLE WALKING

pages.ivillage.comdeadpeoplewalking

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