General fitness, health and nutrition · Public discussion

Caffeine

Started by Alan · · Last activity · 3 posts · 652 views

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General fitness, health and nutrition
Published
13 January 2004
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13 January 2004
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Alan
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  1. A number of times I have asked for some advice here on coffee.
    Basically I'm lazy so it would have been nice for someone else to do
    the work :-)

    No-one did, so here are the results of a little research on Pub Med.

    As I can't survive without my morning fix, I was pleasantly surprised to find this, among other
    references:

    Metabolism studies with coffee and caffeine in healthy subjects, diabetics and patients with
    liver disease.

    [Article in German]

    Studlar M, Pichler O.

    Peroral application of caffeine or theophylline causes a significant increase of the free fatty
    acids and the free glycerol of the serum; blood sugar and cholesterol are not influenced. FFA and
    free glycerol decrease during the day by food intake, blood sugar and triglycerides rise. The
    ingestion of coffee (1-3 cups) does not influence fat and carbohydrate metabolism. To induce a
    significant increase of lipolysis and of serum triglyceride levels high caffeine doses (1000 mg)
    are required.

    Summarizing the data presented, the authors conclude that coffee intake (at dosages compatible with
    normal nutrition) does not deteriorate glucose tolerance and does not interfere with the fat
    metabolism. Our findings are confirmed by epidemiologic investigations which have shown that coffee
    intake is no risk factor for myocardial infarction.

    PMID: 960795 [PubMed - indexed for MEDLINE]
    ncbi.nlm.nih.govquery.fcgi

    tinyurl.comubtw

    The next, and most surprising, result to me was the indication that caffeine may assist recognition
    of early hypo symptoms in Type 1 diabetics:

    The sustained fall in VMCA and augmented sympathoadrenal and symptomatic responses during moderate
    hypoglycaemia suggest caffeine as a potentially useful treatment for diabetic patients who have
    difficulty recognising the onset of hypoglycaemia.

    ncbi.nlm.nih.govquery.fcgi

    tinyurl.comubu0

    The best defense against hypoglycemia is to recognize it: is caffeine useful? ncbi.nlm.n-ncbi.nlm.n-
    ih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11475292&dopt=Abstract

    tinyurl.comubu5

    Ingestion of modest amounts of caffeine enhances the intensity of hypoglycemia warning symptoms in
    patients with type 1 diabetes without altering the prevailing standard of glycemic control or
    increasing the incidence of severe hypoglycemic episodes.

    ncbi.nlm.nih.govquery.fcgi
    t=Abstract

    tinyurl.comubu9

    In patients with Type I diabetes and healthy volunteers, ingestion of modest amounts of caffeine
    augments the usual symptomatic and counter-regulatory responses to hypoglycaemia. The aim of the
    present study was to determine whether these are lost with sustained caffeine use

    ncbi.nlm.nih.govquery.fcgi
    t=Abstract

    tinyurl.comubue

    Cheers Alan, T2, Oz dx May 2002, diet and not enough exercise.
    --
    Everything in Moderation - Except Laughter.

  2. Thanks, I'll take another double shot of espresso!

    Alan said:

    A number of times I have asked for some advice here on coffee. Basically I'm lazy so it would have
    been nice for someone else to do the work :-)

    No-one did, so here are the results of a little research on Pub Med.

    As I can't survive without my morning fix, I was pleasantly surprised to find this, among other
    references:

    Metabolism studies with coffee and caffeine in healthy subjects, diabetics and patients with liver
    disease.

    [Article in German]

    Studlar M, Pichler O.

    Peroral application of caffeine or theophylline causes a significant increase of the free fatty
    acids and the free glycerol of the serum; blood sugar and cholesterol are not influenced. FFA and
    free glycerol decrease during the day by food intake, blood sugar and triglycerides rise. The
    ingestion of coffee (1-3 cups) does not influence fat and carbohydrate metabolism. To induce a
    significant increase of lipolysis and of serum triglyceride levels high caffeine doses (1000 mg)
    are required.

    Summarizing the data presented, the authors conclude that coffee intake (at dosages compatible
    with normal nutrition) does not deteriorate glucose tolerance and does not interfere with the fat
    metabolism. Our findings are confirmed by epidemiologic investigations which have shown that
    coffee intake is no risk factor for myocardial infarction.

    PMID: 960795 [PubMed - indexed for MEDLINE] ncbi.nlm.nih.govquery.fcgi
    rieve&db=PubMed&list_uids=960795&dopt=Abstract

    tinyurl.comubtw

    The next, and most surprising, result to me was the indication that caffeine may assist
    recognition of early hypo symptoms in Type 1 diabetics:

    The sustained fall in VMCA and augmented sympathoadrenal and symptomatic responses during moderate
    hypoglycaemia suggest caffeine as a potentially useful treatment for diabetic patients who have
    difficulty recognising the onset of hypoglycaemia.

    ncbi.nlm.nih.govquery.fcgi
    Abstract

    tinyurl.comubu0

    The best defense against hypoglycemia is to recognize it: is caffeine useful? ncbi.nlm-ncbi.nlm-
    .nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11475292&dopt=Abstract

    tinyurl.comubu5

    Ingestion of modest amounts of caffeine enhances the intensity of hypoglycemia warning symptoms in
    patients with type 1 diabetes without altering the prevailing standard of glycemic control or
    increasing the incidence of severe hypoglycemic episodes.

    ncbi.nlm.nih.govquery.fcgi
    Abstract

    tinyurl.comubu9

    In patients with Type I diabetes and healthy volunteers, ingestion of modest amounts of caffeine
    augments the usual symptomatic and counter-regulatory responses to hypoglycaemia. The aim of the
    present study was to determine whether these are lost with sustained caffeine use

    ncbi.nlm.nih.govquery.fcgi
    Abstract

    tinyurl.comubue

    Cheers Alan, T2, Oz dx May 2002, diet and not enough exercise.
    --
    Everything in Moderation - Except Laughter.

    --
    homepage.mac.commkatzman

  3. "Alan" <[email hidden]>

    Quoted message said:

    As I can't survive without my morning fix, I was pleasantly surprised to find this, among other
    references:

    Quoted message said:

    blood sugar and cholesterol are not influenced.

    Quoted message said:

    Summarizing the data presented, the authors conclude that coffee intake (at dosages compatible
    with normal nutrition) does not deteriorate glucose tolerance and does not interfere

    Hi Alan,

    according to my experience completely wrong. But first of all lets talk about theory. There is a
    study from a certain Garcia in 1993 showing that 250 mg of caffeine (2.5 cups) lead to a rise of
    adrenaline by 207%. Everyone knows that adrenaline stimulates hepatic gluconeogenesis and therefore
    is antagonistic to insulin. Adrenaline is also released with stress which is dangerous for diabetics
    because of high bgs. There is no doubt about it. I´m a t1 since ´73 and last year I sometimes
    enjoyed 5 cups of coffee during 3-4 hours. I wondered at my very high BG 6 hours later. Why? The
    chemical process caffeine => adrenaline => gluconeogenesis => high BG needs 5-6 hours and lasts
    about 6 hours. With 500 mg caffeine I had a real boost of BG up to
    350. I didn´t notice any effect of an extra shot of insulin. Impossible to eat carbs. 6 hours later
    this effect of gluconeogenesis ended.

    Werner

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