Inflammation as a risk factor for atrial fibrillation

On Mon, 05 Jan 2004 11:10:11 +0200, Matti Narkia <[email hidden]>

Quoted message said:

According to the recent study

Aviles RJ, Martin DO, Apperson-Hansen C, Houghtaling PL, Rautaharju P, Kronmal RA, Tracy RP, Van
Wagoner DR, Psaty BM, Lauer MS, Chung MK. Inflammation as a risk factor for atrial fibrillation.
Circulation. 2003 Dec 16;108(24):3006-10. Epub 2003 Nov 17. PMID: 14623805 [PubMed - in process]
<URL:http://circ.ahajournals.org/cgi/content/abstract/108/24/3006>

the systemic inflammation determined by elevations in C-reactive protein (CRP) is associated with
the presence of atrial fibrillation and may also predict patients at increased risk for future
development of atrial fibrillation.

Abstract:

"BACKGROUND: The presence of systemic inflammation determined by elevations in C-reactive
protein (CRP) has been associated with persistence of atrial fibrillation (AF). The
relationship between CRP and prediction of AF has not been studied in a large population-based
cohort. METHODS AND RESULTS: CRP measurement and cardiovascular assessment were performed at
baseline in 5806 subjects enrolled in the Cardiovascular Health Study. Patients were followed
up for a mean of 6.9+/-1.6 (median 7.8) years. AF was identified by self-reported history and
ECGs at baseline and by ECGs and hospital discharge diagnoses at follow-up. Univariate and
multivariate analyses were used to assess CRP as a predictor of baseline and future development
of AF. At baseline, 315 subjects (5%) had AF. Compared with subjects in the first CRP quartile
(<0.97 mg/L), subjects in the fourth quartile (>3.41 mg/L) had more AF (7.4% versus 3.7%,
adjusted OR 1.8, 95% CI 1.2 to
2.5; P=0.002). Of 5491 subjects without AF at baseline, 897 (16%) developed AF during follow-
up. Baseline CRP predicted higher risk for developing future AF (fourth versus first quartile
adjusted hazard ratio 1.31, 95% CI 1.08 to 1.58; P=0.005). When treated as a continuous
variable, elevated CRP predicted increased risk for developing future AF (adjusted hazard
ratio for 1-SD increase, 1.24; 95% CI 1.11 to 1.40; P<0.001). CONCLUSIONS: CRP is not only
associated with the presence of AF but may also predict patients at increased risk for future
development of AF."

I have AF and very low levels of CRP.

Mon, 05 Jan 2004 09:53:09 -0500 in article

Quoted message said:

I have AF and very low levels of CRP.

So? What in your opinion can be concluded about that?

--
Matti Narkia

On Mon, 05 Jan 2004 17:30:30 +0200, Matti Narkia <[email hidden]>

Quoted message said:

Quoted message said:

I have AF and very low levels of CRP.

So? What in your opinion can be concluded about that?

That they are not synonymous?

antwrp.gsfc.nasa.govap031111.htmlOpen ↗ Lift well, Eat less, Walk fast, Live long.

On Mon, 05 Jan 2004 17:30:30 +0200, Matti Narkia <[email hidden]>

Quoted message said:

Mon, 05 Jan 2004 09:53:09 -0500 in article <[email hidden]>

Quoted message said:

I have AF and very low levels of CRP.

So? What in your opinion can be concluded about that?

That, perhaps, a much larger study re: CRP levels and arrythmia needs to be done before substantive
conclusions are drawn.

Mon, 05 Jan 2004 12:51:15 -0500 in article

Quoted message said:

Matti Narkia said:

Mon, 05 Jan 2004 09:53:09 -0500 in article <[email hidden]>

Quoted message said:

I have AF and very low levels of CRP.

So? What in your opinion can be concluded about that?

That, perhaps, a much larger study re: CRP levels and arrythmia needs to be done before substantive
conclusions are drawn.

Well, my guess is that there could be several risk factors for AF and an elevated CRP is just
one of them..

--
Matti Narkia