Neurotherapeutics. 2007 Jul;4(3):371-386.
Iron in Chronic Brain Disorders: Imaging and Neurotherapeutic
Implications.Stankiewicz J, Panter SS, Neema M, Arora A, Batt CE,
Bakshi R.
Department of Neurology, Brigham and Women's Hospital, Harvard Medical
School, Boston, Massachusetts 02115.
Iron is important for brain oxygen transport, electron transfer,
neurotransmitter synthesis, and myelin production. Though iron
deposition has been observed in the brain with normal aging, increased
iron has also been shown in many chronic neurological disorders
including Alzheimer's disease, Parkinson's disease, and multiple
sclerosis. In vitro studies have demonstrated that excessive iron can
lead to free radical production, which can promote neurotoxicity.
However, the link between observed iron deposition and pathological
processes underlying various diseases of the brain is not well
understood. It is not known whether excessive in vivo iron directly
contributes to tissue damage or is solely an epiphenomenon. In this
article, we focus on the imaging of brain iron and the underlying
physiology and metabolism relating to iron deposition. We conclude
with a discussion of the potential implications of iron-related
toxicity to neurotherapeutic development.
PMID: 17599703 [PubMed - as supplied by publisher]
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