British Journal of Dermatology
Volume 116 Issue 1 Page 21 - January 1987
To cite this article: N. JACKSON, D. BURT, J. CROCKER, B. BOUGHTON
(1987)
Skin mast cells in polycythaemia vera relationship to the pathogenesis
and treatment of pruritus
British Journal of Dermatology 116 (1), 21–29.
doi:10.1111/j.1365-2133.1987.tb05787.x
Original Article
Skin mast cells in polycythaemia vera relationship to the pathogenesis
and treatment of pruritus
N. JACKSON11Departments of Haematology, University of Birmingham,
Birmingham, U.K., D. BURT**Departments of Immunology, University of
Birmingham Birmingham, U.K., J. CROCKER††Department of Pathology, East
Birmingham Hospital, Birmingham, U.K. AND B. BOUGHTON11Departments of
Haematology, University of Birmingham, Birmingham, U.K.1Departments of
Haematology, University of Birmingham, Birmingham, U.K.*Departments of
Immunology, University of Birmingham Birmingham, U.K.†Department of
Pathology, East Birmingham Hospital, Birmingham, U.K.
Correspondence: Dr B.J.Boughton, Haematology Department, University of
Birmingham, Queen Elizabeth Medical Centre, Edgbaston, Birmingham B15
2TH, U.K.
SUMMARY
We have measured skin mast cell numbers, circulating basophils and
whole blood histaminc in 13 patients with polycythaemia vera. Itching
was present in nine cases and correlated well with the numbers of skin
mast cells but not with circulating basophils or whole blood
histamine. Immediate relief of pruritus was achieved with aspirin, and
myelosuppressive therapy was useful for long-term control of symptoms.
Neither histamine (H1 or H2) antagonists nor iron replacement therapy
were effective forms of treatment. The findings suggest that mast cell
prostaglandins are an important factor in the pathogenesis of pruritus
and that local vascular responses may trigger mast cell degranulation.
This article is cited by:
A. Baldo, E. Sammarco, R. Plaitano, V. Martinelli and G. Monfrecola.
(2002) Narrowband (TL-01) ultraviolet B phototherapy for pruritus in
polycythaemia vera. British Journal of Dermatology 147:5, 979–981
Abstract Abstract and References Full Text Article Full Article PDF
Jerry L. Spivak. (2002) THE OPTIMAL MANAGEMENT OF POLYCYTHAEMIA VERA.
British Journal of Haematology 116:2, 243–254
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Med Hypotheses 1998 Mar;50(3):239-51
A chelate theory for the mechanism of action of aspirin-like drugs.
[censored] X
Department of Pathology, Cornell University Medical College, New
York,
NY 10021, USA. [email hidden]
Two hundred years after the discovery of the pharmaceutical
usefulness
of aspirin, it and aspirin-like drugs, a family with an
ever-increasing number of members, are an indispensable part of
modern
life. However, the question as to how these drugs work in the body
has
remained unsettled. It is postulated here that this group of drugs
may
exert their therapeutic (and adverse) effects by chelating various
physiologically important metallic cations in the body. The chelate
theory is supported by the vast majority, if not all, of the
observations on these drugs made in the past.
Publication Types:
* Review
* Review, academic
PMID: 9578329, UI: 98237440
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