So one might assume .. colitis also would be exacerbated by ..
barometric .. pressure .. sort of 'immediate' .. marker .. like ..
**pain** .. / or DB's .. ?
<<snip>>
Associations occurred with low barometric pressure
<<snip>>
Clin Allergy. 1988 Jul;18(4):351-8. Links
Biometeorological triggers in childhood asthma.Khot A, Burn R, Evans
N, Lenney W, Storr J.
Royal Alexandra Hospital for Sick Children, Brighton, East Sussex.
The relationship between child asthma admissions and biometeorological
factors was investigated over a 16-month period. No relationship was
found with many commonly suspected precipitants such as temperature,
humidity and wind. There was however a strong association with
rainfall (P much less than 0.001). Associations occurred with low
barometric pressure and counts of coloured basidiospores and green
algae, but no significant relationship was found with grass pollen.
PMID: 3416418 [PubMed - indexed for MEDLINE]
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http://www.usatoday.com/weather/resources/safety/2005-02-21-health-pressure_x.htm
Scientists still mulling causes of weather-related pain
By April Chan, USATODAY.com
Migraine sufferers and people with joint problems such as rheumatoid
arthritis often declare that they are better predictors of inclement
weather than the most seasoned forecaster.
--------------------------------------------------------------------------
It seems low barometric pressure / altitude .. brings on .. "very
discreet polycythemia frequently found during the first hours" .. or
the .. "polycythemic process " .. increased red blood cell
production.
Increased red blood cell production .. increasing viscosity ..
mimicing .. altitude .. which 'coincidentally' .. manifests itself ..
as .. headaches or .. migraine .. or .. arthritis ..
Therefore linking .. **again** .. increased red blood cell production
leading TO .. PREceding .. arthritis and / or .. asthma ..
<<snip>>
The observations carried out permit the following conclusions:
1. The polycythemic process of subjects with anoxia caused by a low
pressure environment is due to a greater blood formation by the
hematopoietic organs. This becomes manifest after forty-eight hours.
The very discreet polycythemia frequently found during the first hours
is probably the result of hemoconcentration and release of stored
blood.
<<snip>>
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/5/1/1?ck=nck
Blood, 1950, Vol. 5, No. 1, pp. 1-31.
© 1950 American Society of Hematology, Inc.
--------------------------------------------------------------------------------
STUDIES ON BLOOD FORMATION AND DESTRUCTION IN THE POLYCYTHEMIA OF HIGH
ALTITUDE
CÉSAR F. MERINO M.D.1
1 Department of Pathological Physiology and the Institute of Andean
Biology of the Faculty of Medicine, Lima, Peru.
Studies of blood formation and destruction in the polycythemia of high
altitude have been carried out. Three different groups of subjects
were studied:
1. Healthy adult male subjects from sea level who, after being studied
at this level, were taken to an altitude of 4,540 meters (Morococha)
where they developed a marked polycythemic process. When these
subjects returned to sea level, the mechanisms of recuperation of the
hematologic equilibrium were studied.
Normal adult subjects, natives of high altitude, chronically
polycythemic due to their permanent residence in Morococha, who were
first studied in their native town and then brought to sea level where
they were observed during five weeks.
3. Subjects, residents of high altitude (Morococha), who had lost
their adaptation to it; i.e. who had developed chronic altitude
sickness or Soroche (Monge's malady).
The observations carried out permit the following conclusions:
1. The polycythemic process of subjects with anoxia caused by a low
pressure environment is due to a greater blood formation by the
hematopoietic organs. This becomes manifest after forty-eight hours.
The very discreet polycythemia frequently found during the first hours
is probably the result of hemoconcentration and release of stored
blood.
2. This polycythemic process is not accompanied by quantitative
alterations of the leukocytes nor of the platelets; thus, differing
from polycythemia vera, in which there is as a rule an increase in all
the hematologic elements.
3. The increased blood volume of residents at high altitude is due
exclusively to the increased red cell mass, the plasma volume being
more likely to be found diminished.
4. In normal subjects who are temporarily or permanently exposed to an
atmosphere of low barometric pressure, the excretion of fecal
urobilinogen does not exceed the limits considered normal at sea
level, but increases with relation to the larger circulatory
hemoglobin mass, a normal hemolytic index being maintained.
5. The hyperbilirubinemia very frequently found in the natives and in
those resident for a long time at high altitudes appears to be related
to a lesser excretion of this pigment by the liver, probably on the
basis of the anoxic state. The greater production of bilirubin in
subjects at high altitude is not sufficient to explain, in and of
itself, the pigmentary elevation in the blood.
6. The mechanism of the disappearance of the polycythemia when the
subjects from a high altitude are brought to sea level, appears to be
as follows: (a) temporary diminution or inhibition of erythropoiesis,
and (b) a greater blood destruction. The latter takes place only
during the first days of stay at sea level, being chiefly responsible
for the early rapid decrease of the degree of polycythemia, while the
former acts in a more prolonged form and is principally responsible
for the erythropoietic "normalization."
7. In two cases of chronic altitude sickness, or chronic Soroche
(Monge's disease), the output of fecal urobilinogen exceeded
proportionally the increase of the circulatory hemoglobin mass. The
hemolytic index was found abnormally high.
8. The above findings indicate that the polycythemia of the normal
individual residing at high altitudes is characterized by a
proportional and direct accentuation in the processes of blood
formation and destruction. On the other hand, in those subjects also
residing at high altitudes, who exhibit an abnormally high
polycythemia (chronic Soroche), the accentuation in the processes of
blood destruction is proportionally greater than that corresponding to
the greater erythropoiesis. This characteristic constitutes a possible
diagnostic criterion and can perhaps explain in part the etiologic
mechanism of this alteration.
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