Conclusion: "All of these studies suggest that curcumin has
enormous potential in the prevention and therapy of cancer."
Anticancer Research. 2003 Jan-Feb;23(1A):363-98
Anticancer potential of curcumin: preclinical and clinical studies.
Aggarwal BB, Kumar A, Bharti AC.
Cytokine Research Section, Department of Bioimmunotherapy, University of Texas M. D. Anderson Cancer
Center, 1515 Holcombe Boulevard, Box 143, Houston, TX, USA. [email hidden]
Curcumin (diferuloylmethane) is a polyphenol derived from the plant Curcuma longa, commonly called
turmeric. Extensive research over the last 50 years has indicated this polyphenol can both prevent
and treat cancer. The anticancer potential of curcumin stems from its ability to suppress
proliferation of a wide variety of tumor cells, down-regulate transcription factors NF-kappa B, AP-1
and Egr-1; down-regulate the expression of COX2, LOX, NOS, MMP-9, uPA, TNF, chemokines, cell surface
adhesion molecules and cyclin D1; down-regulate growth factor receptors (such as EGFR and HER2); and
inhibit the activity of c-Jun N-terminal kinase, protein tyrosine kinases and protein
serine/threonine kinases. In several systems, curcumin has been described as a potent antioxidant
and anti-inflammatory agent. Evidence has also been presented to suggest that curcumin can suppress
tumor initiation, promotion and metastasis. Pharmacologically, curcumin has been found to be safe.
Human clinical trials indicated no dose-limiting toxicity when administered at doses up to 10 g/day.
All of these studies suggest that curcumin has enormous potential in the prevention and therapy of
cancer. The current review describes in detail the data supporting these studies.
ncbi.nlm.nih.govquery.fcgiOpen ↗
t=Abstract
Report on Curcumin's Anti-Cancer Effects:
lef.orgjul2002 report curcumin 01.htmlOpen ↗
iangoddard.netiangoddard.netOpen ↗
"To lengthen thy life, lessen thy meals." Ben Franklin
Ongoing CR-monkey-study update: "In the monkeys...those on reduced feeding since the study started
are dying at a rate that is about half that of the monkeys receiving a full food ration."
Associated Press: Eating less may extend human life. August 1, 2002 :
msnbc.com788746.aspOpen ↗