Quoted message said:Subject: Re: autoimmune disease
Autoimmune disease is found in this part of the gene ..
autoimmune SLC11A1 iron overload SLC11A3
Allergies fall in autoimmune disease .
This article speaks to the finding of transferrin / iron storage protein in the incidence of
allergic anaphylactic shock.
'Free' iron plays the same role as saturated transferrin .. as some sort of catalyst?
Does this say free iron / oxidation is 'bad'..?
Is easier to go into anaphylactic shock if the transferrin is MORE or LESS 'saturated'..?
Ann Inst Pasteur Immunol 1987 Mar-Apr;138(2):213-21
Biological effect of transferrin on mast cell mediator release during the passive cutaneous
anaphylaxis reaction: a possible inhibition mechanism involving iron.
Mecheri S, Peltre G, Lapeyre J, David B A purification procedure for passive cutaneous anaphylaxis
inhibitory factor from BALB/c mouse serum has been previously described. In the present work, this
inhibitory activity was found to be related to transferrin. No activity was obtained using
iron-unsaturated transferrin, whereas iron-saturated transferrin appeared to be potent. The in vivo
inhibition of IgE-dependent mediator release from rat mast cells was also obtained using free iron.
This effect was observed when iron was injected prior to or simultaneously with mouse IgE in rat
skin. Iron and iron-saturated transferrin could play a role in the mechanism of desensitization by
modulating the responsiveness of mast cells.
PMID: 2440461, UI: 87271172
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