<<snip>>
This is the first report to directly demonstrate an association between
serum ferritin and VFA and SFA. The results of this study suggest that
the serum ferritin concentration may be a useful indicator of systemic
fat content and degree of insulin resistance.
<<snip>>
© 2005 by the American Diabetes Association
Diabetes Care 28:2486-2491, 2005
© 2005 by the American Diabetes Association, Inc.
--------------------------------------------------------------------------------
Metabolic Syndrome/Insulin Resistance Syndrome/Pre-Diabetes
Original Article
Serum Ferritin Is Associated With Visceral Fat Area and Subcutaneous
Fat Area
Tomoyuki Iwasaki, MD, PHD1, Atsushi Nakajima, MD, PHD2, Masato Yoneda,
MD, PHD2, Yoshihiko Yamada, MD, PHD1, Koji Mukasa, MD, PHD1, Koji
Fujita, MD2, Nobutaka Fujisawa, MD, PHD2, Koichiro Wada, MD, PHD3 and
Yasuo Terauchi, MD, PHD1,4
1 Department of Endocrinology and Metabolism, Yokohama City University
Graduate School of Medicine, Yokohama, Japan
2 Department of Gastroenterology, Yokohama City University Graduate
School of Medicine, Yokohama, Japan
3 Department of Pharmacology, Graduate School of Dentistry, Osaka
University, Osaka, Japan
4 Core Research for Evolutional Science and Technology (CREST), Japan
Science and Technology Corporation, Kawaguchi, Japan
Address correspondencereprint requests to Prof. Yasuo Terauchi,
Department of EndocrinologyMetabolism, Yokohama City University
Graduate School of Medicine, 3-9 [censored], Kanazawa-ku, Yokohama
236-0004, Japan. Email: [email hidden]
OBJECTIVE-Until now, few clinical studies have reported on the
association between the indexes of body fat distribution and serum
ferritin, an indicator of body iron stores and a putative risk factor
for insulin resistance. We investigated the association between serum
ferritin concentrations and the indexes of distribution of adipose
tissues in the body, such as the visceral fat area (VFA), the
subcutaneous fat area (SFA), and the hepatic fat content in Japanese
subjects.
RESEARCH DESIGN AND METHODS-A total of 248 Japanese subjects (127 men
and 121 postmenopausal women aged 57.8 ± 13.9 years, BMI 25.7 ± 4.6
kg/m2; 140 subjects with type 2 diabetes and 108 nondiabetic subjects)
were evaluated. Subjects with a history of alcohol intake were excluded
from the study. We measured body height, body weight, and serum
ferritin, as well as fasting plasma glucose and plasma insulin
concentrations. We estimated insulin resistance by homeostasis model
assessment. The fat distribution was evaluated by measuring the VFA and
SFA by abdominal computed tomography at the umbilical level. To assess
the hepatic fat content, the ratio of the computed tomography
attenuation value of the liver to that of the spleen was calculated.
RESULTS-Serum ferritin was significantly correlated with the various
indexes of adiposity examined, such as the hepatic fat content (r =
-0.280, P < 0.0001), VFA (r = 0.254, P < 0.0001), SFA (r = 0.231, P =
0.0005), and homeostasis model assessment (r = 0.286, P = 0.0008).
CONCLUSIONS-This is the first report to directly demonstrate an
association between serum ferritin and VFA and SFA. The results of this
study suggest that the serum ferritin concentration may be a useful
indicator of systemic fat content and degree of insulin resistance.
Abbreviations: CT, computed tomography · HOMA-IR, homeostasis model
assessment of insulin resistance · L/S ratio, ratio of the CT
attenuation value of the liver to that of the spleen · SFA,
subcutaneous fat area · VFA, visceral fat area
--------------------------------------------------------------------------------
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