Policosanol anyone?

On Mon, 24 Nov 2003 01:46:57 GMT, nospam <[email hidden]>

Quoted message said:

Is anyone here using Policosanol to control their Tris and Cholesterol?

It did nothing for me, taking 10mg/day of policosanol from suger cane
wax (which is the only form for which there is any real research).

nospam said:

Is anyone here using Policosanol to control their Tris and Cholesterol?

I am. 20 mg daily, in addition to red yeast rice, niacin, fish oil, and
guggulipid.

http://tinyurl.com/xepg

--
~~~
Patrick Blanchard, M.D., A.B.F.P.
Board Certified in Family Practice
http://www.familydoctor.org/blanchard
~~~
SonoScore
Winning against heart attack and stroke
http://www.sonoscore.com

Tue, 02 Dec 2003 13:27:42 -0600 in article
<[email hidden]> "Patrick Blanchard, M.D."

blanchard@sonoscore_nospam.com said:

nospam said:

Is anyone here using Policosanol to control their Tris and Cholesterol?

I am. 20 mg daily, in addition to red yeast rice, niacin, fish oil, and
guggulipid.

Policosanol has some documented efficacy (although almost all of the
research has been done in Cuba, so do red yeast rice (
http://tinyurl.com/xfnv ) (one of its active ingredients is
naturally-occurring statin lovastatin), niacin and fish oil, but
guggulipid recently failed in a randomized controlled clinical trial:

Szapary PO, Wolfe ML, Bloedon LT, Cucchiara AJ, DerMarderosian AH,
Cirigliano MD, Rader DJ.
Guggulipid for the treatment of hypercholesterolemia: a randomized
controlled trial.
JAMA. 2003 Aug 13;290(6):765-72.
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12915429&dopt=Abstract>
( http://tinyurl.com/xfp8 )

Patrick Blanchard said:

nospam said:

Is anyone here using Policosanol to control their Tris and Cholesterol?

I am. 20 mg daily, in addition to red yeast rice, niacin, fish oil, and
guggulipid.

http://tinyurl.com/xepg

--
~~~
Patrick Blanchard, M.D., A.B.F.P.
Board Certified in Family Practice
http://www.familydoctor.org/blanchard

Welcome back, Patrick. Missed our discussions :-)

Out of curiosity, what was your fasting lipid profile *before* that
combination that you are currently taking?

And why not lovastatin instead of red yeast rice?

Humbly,

Andrew

--
Dr. Andrew B. Chung, MD/PhD
Board-Certified Cardiologist
http://www.heartmdphd.com

http://tinyurl.com/xjcvOn Wed, 03 Dec 2003 00:23:54 +0200, Matti Narkia

Quoted message said:

Tue, 02 Dec 2003 13:27:42 -0600 in article
<[email hidden]> "Patrick Blanchard, M.D."

blanchard@sonoscore_nospam.com said:

nospam said:

Is anyone here using Policosanol to control their Tris and Cholesterol?

I am. 20 mg daily, in addition to red yeast rice, niacin, fish oil, and
guggulipid.

Policosanol has some documented efficacy (although almost all of the
research has been done in Cuba, so do red yeast rice (
http://tinyurl.com/xfnv ) (one of its active ingredients is
naturally-occurring statin lovastatin), niacin and fish oil, but
guggulipid recently failed in a randomized controlled clinical trial:

Szapary PO, Wolfe ML, Bloedon LT, Cucchiara AJ, DerMarderosian AH,
Cirigliano MD, Rader DJ. Guggulipid for the treatment of
hypercholesterolemia: a randomized
controlled trial.
JAMA. 2003 Aug 13;290(6):765-72.
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12915429&dopt=Abstract>

( http://tinyurl.com/xfp8 )

This is an interesting study, but 2 things concern me about it:

1. participants were following a westernized diet, which by itself
introduces a lot of noise into the data.
2. LDL-C was the outcome, not LDL subclasses.

However, a more controlled group can be found here that also supports your
study about the washout of LDL-C.

http://tinyurl.com/xjcv

Other benefits of guggul appear to be antioxidation. guggul also believed
to inhibit platelet aggregation.

It's safety of use beyond 6 months is not clear.

Its use, however, should be adjunctive, or with other measures to achive
treatment goals.

--
~~~
Patrick Blanchard, M.D., A.B.F.P.
Board Certified in Family Practice
http://www.familydoctor.org/blanchard
~~~
SonoScore
Winning against heart attack and stroke
http://www.sonoscore.com