Contrast-induced nephropathy: Pharmacological prophylaxis.
Briguori C, Marenzi G
Kidney Int. 2006 Apr ; 69(S100): S30-S38
Contrast media-associated acute renal failure represents the third most
common cause of in-hospital renal function deterioration after
decreased renal perfusion and post-operative renal insufficiency.
Although generally benign, this complication is associated with a
mortality rate ranging from 3.8 to 64%, depending on the increase of
creatinine concentration. Multiple drugs have been tested in an attempt
to prevent this complication. Central to the pathophysiology of
contrast-induced nephrotoxicity (CIN) is an alteration in renal
hemodynamics. In an effort to reverse these hemodynamic changes,
vasodilators and diuretics have been tested as prophylactic drugs.
However, their effectiveness has not been confirmed. Recently,
considerable interest has resulted from the initial positive data on
the effectivess of prophylactic administration of antioxidant
compounds, such as acetylcysteine and ascorbic acid. In this review, we
focus on the effectiveness of pharmacologic therapies for preventing
CIN.Kidney International (2006) 69, S30-S38. doi:10.1038/sj.ki.5000372.
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You .. DO .. know ..IRON is in the contrast .. ?
Because it is .. seen . so nicely ..
Who loves ya.
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