Watch your crossposts
Quoted post said:Effects of transferrin receptor blockade on cancer cell proliferation
and hypoxia-inducible factor function and their differential regulation
by ascorbate.
http://en.wikipedia.org/wiki/Vitamin_C
Vitamin C is a water-soluble nutrient essential for life, used by the human
body for many purposes. It is one of a number of such key nutrients called
vitamins.
To the best of scientific knowledge, all animals and plants synthesize
their own vitamin C, except for humans and a small number of other animals,
including, apes, guinea pigs, the red-vented bulbul, a fruit-eating bat and
a species of trout. This has led a minority of scientists, most notably
Linus Pauling to conclude that failure to produce the chemical by an animal
species is a genetic defect and to hypothesize that if it were replaced in
humans to the level found in animals better health would result.
Vitamin C was first isolated in 1928, and in 1932 it was proved to be the
agent which prevents scurvy. In 1937 Albert Szent-Györgyi was awarded the
Nobel Prize for this feat.
Vitamin C is a weak acid, called ascorbic acid or ascorbate (an
L-enantiomer of ascorbic acid; an L-enantiomer is simply one of two mirror
image forms of the same chemical molecular structure, see optical isomers).
The active part of the substance is the ascorbate ion, which can express
itself as either an acid or a salt of ascorbate that is neutral or slightly
basic. Commercial vitamin C is often a mix of ascorbic acid, sodium
ascorbate and/or other ascorbates. Some supplements contain in part the
D-enantiomer, which is useless but harmless. See the ascorbic acid article
for a full description of the molecule's chemical properties.
Quoted message said:Jones DT, Trowbridge IS, Harris AL Cancer Res. 2006 Mar 1; 66(5): 2749-56
[...] The use of anti-TfR mAbs and ascorbate in inhibiting
both cell proliferation and HIF-1alpha and angiogenesis under normoxic
conditions may be of therapeutic use. (Cancer Res 2006; 66(5): 2749-56).