Question:

Quoted message said:

Hi, I was wondering if anyone could help me with sumthing.

Is it bad to drink orange juice in conjunction with medicine and
supplements???

My parents tell me its bad for my stomach if I do that, but I think its
a load of [censored].

Orange juice is very acidic and full of sugar. I would not drink it
with medication. Apply some sommon sense and drink water.

TC

Quoted message said:

Hi, I was wondering if anyone could help me with sumthing.

Is it bad to drink orange juice in conjunction with medicine and
supplements???

My parents tell me its bad for my stomach if I do that, but I think its
a load of [censored].

COMMENT:
Your parents are always right. They never give orange juice in
hospitals with medications. Not.

In article <[email hidden]>,

Sbharrisatsignix.netcom.com said:

Quoted message said:

Hi, I was wondering if anyone could help me with sumthing.

Is it bad to drink orange juice in conjunction with medicine and
supplements???

My parents tell me its bad for my stomach if I do that, but I think its
a load of [censored].

COMMENT:
Your parents are always right. They never give orange juice in
hospitals with medications. Not.

Actually, most give grape and apple.......
--
Om.

"My mother never saw the irony in calling me a son-of-a-[censored]." -Jack Nicholson

Orange juice has been associated with bronchial , lung and sinus problems.

"OmManiPadmeOmelet" <[email hidden]> wrote in message
news:[email hidden]...
In article <[email hidden]>,

Sbharrisatsignix.netcom.com said:

Quoted message said:

Hi, I was wondering if anyone could help me with sumthing.

Is it bad to drink orange juice in conjunction with medicine and
supplements???

My parents tell me its bad for my stomach if I do that, but I think its
a load of [censored].

COMMENT:
Your parents are always right. They never give orange juice in
hospitals with medications. Not.

Actually, most give grape and apple.......
--
Om.

"My mother never saw the irony in calling me a son-of-a-[censored]." -Jack
Nicholson

On Fri, 23 Sep 2005 17:24:08 -0400, "Pizza Girl." <[email hidden]>
wrote:

If your blood type is O, AB or A, orange/orange juice will cause the
'sour stomach' phenomenon (caused by increased polyamine production).

It's OK for B's.

Steve

Quoted message said:

Orange juice has been associated with bronchial , lung and sinus problems.

"OmManiPadmeOmelet" <[email hidden]> wrote in message
news:[email hidden]...
In article <[email hidden]>,

Sbharrisatsignix.netcom.com said:

Quoted message said:

Hi, I was wondering if anyone could help me with sumthing.

Is it bad to drink orange juice in conjunction with medicine and
supplements???

My parents tell me its bad for my stomach if I do that, but I think its
a load of [censored].

COMMENT:
Your parents are always right. They never give orange juice in
hospitals with medications. Not.

Actually, most give grape and apple.......

Quoted message said:

Hi, I was wondering if anyone could help me with sumthing.

Is it bad to drink orange juice in conjunction with medicine and
supplements???

My parents tell me its bad for my stomach if I do that, but I think its
a load of [censored].

Your parents are right. I'm a parent. I'm right.

Don't take your meds with any citrus; orange, grapefruit, pommelos
(hybrids of grapefruit) etc. Not with the juice or the whole fruit.

The Parents' Rule on Swilling Juice with Meds is this:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16048354&query_hl=1

Drug Saf. 2005;28(8):677-94.
Undesirable effects of citrus juice on the pharmacokinetics of drugs:
focus on recent studies.

Saito M, Hirata-Koizumi M, Matsumoto M, Urano T, Hasegawa R.

Division of Medicinal Safety Science, National Institute of Health
Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
[email hidden]

It is well known that intake of grapefruit juice affects the
pharmacokinetics of various kinds of drugs. It has been reported that
other citrus juices also interact with certain drugs. To re-evaluate
citrus juice-drug interactions based on currently available evidence, a
literature search was conducted for new and updated information since
the grapefruit juice-drug interaction was last reviewed in 1998.
MEDLINE (1998-October 2004) was accessed and more than 200 reports were
found. The effects of grapefruit juice ingestion on the
pharmacokinetics of orally administered drugs have been reported for 40
drugs since the reviews published in 1998. Increases in either area
under the concentration-time curve (AUC) or maximum plasma
concentration (C(max)) were found with 34 of these, the major mechanism
being considered to be inactivation of intestinal cytochrome P450 3A4,
a so-called mechanism-based inhibition. Although recent reports point
to the inhibitory effects of grapefruit juice on the function of
P-glycoprotein, which transports substrates from enterocytes back into
the lumen, the contribution to the bioavailability of drugs that are
substrates of P-glycoprotein has not been established yet. Dramatic
decreases in AUC and C(max) for two drugs in association with
grapefruit juice ingestion has been reported and, in these cases,
inhibitory effects on organic anion transporting polypeptide, which
mediates absorption from the intestinal lumen to enterocytes, might be
involved. Other citrus juices such as Seville (sour) orange juice and
commonly ingested varieties of orange juice also showed significant
effects on the AUC and C(max) of some drugs. Although the situation is
complex and uncertainties remain, we recommend that patients avoid
citrus juice intake while taking medications and that healthcare
providers advise against citrus juice intake in this setting until any
interactions with subject drugs can be clarified in clinical studies.

PMID: 16048354 [PubMed - in process]

Quoted message said:

Quoted message said:

Hi, I was wondering if anyone could help me with sumthing.

Is it bad to drink orange juice in conjunction with medicine and
supplements???

My parents tell me its bad for my stomach if I do that, but I think its
a load of [censored].

Your parents are right. I'm a parent. I'm right.

Don't take your meds with any citrus; orange, grapefruit, pommelos
(hybrids of grapefruit) etc. Not with the juice or the whole fruit.

The Parents' Rule on Swilling Juice with Meds is this:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16048354&query_hl=1

Drug Saf. 2005;28(8):677-94.
Undesirable effects of citrus juice on the pharmacokinetics of drugs:
focus on recent studies.

Saito M, Hirata-Koizumi M, Matsumoto M, Urano T, Hasegawa R.

Division of Medicinal Safety Science, National Institute of Health
Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
[email hidden]

It is well known that intake of grapefruit juice affects the
pharmacokinetics of various kinds of drugs. It has been reported that
other citrus juices also interact with certain drugs. To re-evaluate
citrus juice-drug interactions based on currently available evidence, a
literature search was conducted for new and updated information since
the grapefruit juice-drug interaction was last reviewed in 1998.
MEDLINE (1998-October 2004) was accessed and more than 200 reports were
found. The effects of grapefruit juice ingestion on the
pharmacokinetics of orally administered drugs have been reported for 40
drugs since the reviews published in 1998. Increases in either area
under the concentration-time curve (AUC) or maximum plasma
concentration (C(max)) were found with 34 of these, the major mechanism
being considered to be inactivation of intestinal cytochrome P450 3A4,
a so-called mechanism-based inhibition. Although recent reports point
to the inhibitory effects of grapefruit juice on the function of
P-glycoprotein, which transports substrates from enterocytes back into
the lumen, the contribution to the bioavailability of drugs that are
substrates of P-glycoprotein has not been established yet. Dramatic
decreases in AUC and C(max) for two drugs in association with
grapefruit juice ingestion has been reported and, in these cases,
inhibitory effects on organic anion transporting polypeptide, which
mediates absorption from the intestinal lumen to enterocytes, might be
involved. Other citrus juices such as Seville (sour) orange juice and
commonly ingested varieties of orange juice also showed significant
effects on the AUC and C(max) of some drugs. Although the situation is
complex and uncertainties remain, we recommend that patients avoid
citrus juice intake while taking medications and that healthcare
providers advise against citrus juice intake in this setting until any
interactions with subject drugs can be clarified in clinical studies.

PMID: 16048354 [PubMed - in process]

Well, how about that? The things you find out, if you look.

However, I'd bet that if you systematically examined every other class
of plant food-- maybe any food-- you'd also find some shocking
surprises on effects on biavailability of specific drugs. We usually
just close our eyes and ignore this stuff, unless it's an inhibitor
which leads to greatly INCREASED blood levels, as with the grapefruit
P450 interaction mentioned. For other drugs, people eating a given meal
probably just miss an occasional amount of drug and never notice.

I'll keep the juice-law in mind!

SBH

Sbharrisatsignix.netcom.com said:

Quoted message said:

Quoted message said:

Hi, I was wondering if anyone could help me with sumthing.

Is it bad to drink orange juice in conjunction with medicine and
supplements???

My parents tell me its bad for my stomach if I do that, but I think its
a load of [censored].

Your parents are right. I'm a parent. I'm right.

Don't take your meds with any citrus; orange, grapefruit, pommelos
(hybrids of grapefruit) etc. Not with the juice or the whole fruit.

The Parents' Rule on Swilling Juice with Meds is this:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16048354&query_hl=1

Drug Saf. 2005;28(8):677-94.
Undesirable effects of citrus juice on the pharmacokinetics of drugs:
focus on recent studies.

Saito M, Hirata-Koizumi M, Matsumoto M, Urano T, Hasegawa R.

Division of Medicinal Safety Science, National Institute of Health
Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
[email hidden]

It is well known that intake of grapefruit juice affects the
pharmacokinetics of various kinds of drugs. It has been reported that
other citrus juices also interact with certain drugs. To re-evaluate
citrus juice-drug interactions based on currently available evidence, a
literature search was conducted for new and updated information since
the grapefruit juice-drug interaction was last reviewed in 1998.
MEDLINE (1998-October 2004) was accessed and more than 200 reports were
found. The effects of grapefruit juice ingestion on the
pharmacokinetics of orally administered drugs have been reported for 40
drugs since the reviews published in 1998. Increases in either area
under the concentration-time curve (AUC) or maximum plasma
concentration (C(max)) were found with 34 of these, the major mechanism
being considered to be inactivation of intestinal cytochrome P450 3A4,
a so-called mechanism-based inhibition. Although recent reports point
to the inhibitory effects of grapefruit juice on the function of
P-glycoprotein, which transports substrates from enterocytes back into
the lumen, the contribution to the bioavailability of drugs that are
substrates of P-glycoprotein has not been established yet. Dramatic
decreases in AUC and C(max) for two drugs in association with
grapefruit juice ingestion has been reported and, in these cases,
inhibitory effects on organic anion transporting polypeptide, which
mediates absorption from the intestinal lumen to enterocytes, might be
involved. Other citrus juices such as Seville (sour) orange juice and
commonly ingested varieties of orange juice also showed significant
effects on the AUC and C(max) of some drugs. Although the situation is
complex and uncertainties remain, we recommend that patients avoid
citrus juice intake while taking medications and that healthcare
providers advise against citrus juice intake in this setting until any
interactions with subject drugs can be clarified in clinical studies.

PMID: 16048354 [PubMed - in process]

Well, how about that? The things you find out, if you look.

However, I'd bet that if you systematically examined every other class
of plant food-- maybe any food-- you'd also find some shocking
surprises on effects on biavailability of specific drugs. We usually
just close our eyes and ignore this stuff, unless it's an inhibitor
which leads to greatly INCREASED blood levels, as with the grapefruit
P450 interaction mentioned. For other drugs, people eating a given meal
probably just miss an occasional amount of drug and never notice.

I'll keep the juice-law in mind!

SBH

There's an ongoing Parent's Observational Study on Pure Black Cherry,
Pomegranete and Cranberry Juice Swilling with Meds ....

....too.

I've put out a call to experts. Stay tuned...

A. Parent

Does for me.

"sTeve" <[email hidden]> wrote in message
news:[email hidden]...
On Fri, 23 Sep 2005 17:24:08 -0400, "Pizza Girl." <[email hidden]>
wrote:

If your blood type is O, AB or A, orange/orange juice will cause the
'sour stomach' phenomenon (caused by increased polyamine production).

It's OK for B's.

Steve

Quoted message said:

Orange juice has been associated with bronchial , lung and sinus problems.

"OmManiPadmeOmelet" <[email hidden]> wrote in message
news:[email hidden]...
In article <[email hidden]>,

Sbharrisatsignix.netcom.com said:

Quoted message said:

Hi, I was wondering if anyone could help me with sumthing.

Is it bad to drink orange juice in conjunction with medicine and
supplements???

My parents tell me its bad for my stomach if I do that, but I think its
a load of [censored].

COMMENT:
Your parents are always right. They never give orange juice in
hospitals with medications. Not.

Actually, most give grape and apple.......