"Profound changes in our environment began with the introduction
of agriculture and animal husbandry 10,000 years ago, too recent
on an evolutionary time scale for the human genome to adjust."
Two cautions:
The life of people who followed their animals and lived almost
exclusively off them (bison and caribou in North America,
reindeer in northern Asia) began much more than 10k years ago.
Recent evolutionary research (Y-chromosome and mitochondrial DNA)
shows that human evolution through selection is much faster than
previously expected. For example, virtually all the population of
today's Europe derives from 10 or so males less than 20k years
ago. 0.5% of the world's human population has as ancestor one
male ca. 1000 years ago. Female ancestry scale seems to be a bit
longer, but not much...