I use a Selle San Marco Era saddle. Before that, I rode the stock saddle that came on my Fuji bike. I was quite comfortable with the Fuji saddle, which didn't have a hole, but did have sort of a trench down the middle. But that seat got ripped up when I endo'ed one day.
I lucked out when I got the Selle San Marco, because it felt comfortable from day one, no matter how far I rode. In contrast, I recently bought a new bike that came with a Fi'zi:k Arione saddle. The salesman at the LBS bragged about how comfortable the saddle was. It was okay on shorter rides -- 20-25 miles or so. But after I did a 62-mile ride one weekend, for several days I was numb and tingling in places that a man doesn't like to be numb and tingling! :eek: So I switched the Selle San Marco saddle over to the new bike and put the Fi'zi:k one on the shelf.
From what I've read, though, saddle comfort is a personal thing. What feels good to me might feel awful to someone else. Like I said, many people rave about the Fi'zi:k saddle, but it didn't work for me.
BTW: Anyone interested in a barely used Fi'zi:k Arione saddle?