Put in enzymes + cancer on pubmed.org. Then if you want to narrow the
results even more, put in enzymes + cancer + Beard.
Here's just one article I picked at random:
: Anticancer Res. 2005 Mar-Apr;25(2A):1157-77.
Proenzyme therapy of cancer.
Novak JF, Trnka F.
Bucknell University, Department of Biology, Lewisburg, Pennsylvania 17837,
USA. [email hidden]
Proteases and their inhibitors have long been investigated in numerous tumor
systems, and at the tumor growing front, their balance has been universally
found to be shifted towards higher proteolytic activities. However, out of
many promising serine and metalloproteinase inhibitors, none are included in
cancer treatment regimens at present. The current search for active
antiproteolytic compounds is in contrast to the classical approach developed
by John Beard, who suggested treating advanced cancer by fresh pancreatic
extracts whose antitumor activity was based on their proteolytic potential.
We followed John Beard's recommendations by using purified pancreatic
proenzymes/enzymes, trypsinogen/trypsin (TG/TR),
chymotrypsinogen/chymotrypsin (CG/CH) and amylase (AM). The mixture of these
enzymatic activities produces potent antimetastatic and antitumor effects in
cellular, animal and human systems. The treatment of cultured tumor cells
with TR and CH at picomolar concentrations, comparable to those achieved in
the blood of the patients, causes complete arrest of the directional
movement of metastatic cells. Conversely, the same treatment of normal cells
results in enhanced motility and an accelerated closure of the gap created
in cell monolayers. Further, treatment of cells with serine proteases
results in the formation of cellular 3-dimensional structures such as
lamellae, cell streams and aggregates. In some cell types, the aggregates
are compacted via cadherin-based cell-cell communication systems and form
compact spheroids. In the highly metastatic cells with lower cadherin
expression, the ability to form spheroids also diminishes. Tumor cells
unable to form spheroids when treated with proteases are subject to
elimination by apoptosis. In contrast, a large proportion of cells that form
spheroids remain viable, although they are metabolically suppressed.
Protease-treated tumor cells contain a disrupted actin cytoskeleton and
exhibit a loss of front-to-back polarity. We hypothesize that the provision
of zymogens, rather than the enzymes, was of crucial importance to the
clinical effectiveness in the human trials conducted by Beard and his
co-workers. The precursor nature of the active enzymes may offer protection
against numerous serpins present in the tissues and blood. Experimental
evidence supports the assertion that the conversion from proenzyme to enzyme
occurs selectively on the surface of the tumor cells, but not on normal
cells. We believe that this selectivity of activation is responsible for the
antitumor/antimetastatic effect of proenzyme therapy and low toxicity to
normal cells or tumor host. Elevated levels of endostatin and angiostatin
appear in the blood of TG/CG/AM-treated tumor-bearing mice, but not in tumor
mice treated with the vehicle alone or in proenzyme-treated tumor-free mice.
These findings support the conclusion that proteolysis is the active
mechanism of the proenzyme treatment. Future studies will focus on the
molecular mechanisms of the proenzyme therapy including the identification
of molecular target(s) on the tumor cells. In conclusion, we have discovered
that proenzyme therapy, mandated first by John Beard nearly one hundred
years ago, shows remarkable selective effects that result in growth
inhibition of tumor cells with metastatic potential.
PMID: 15868959 [PubMed - indexed for MEDLINE]
****
It seems if people had not been so quick to jump on the "Saint" Madame Curie
bandwagon which thought radiation was the answer to everything, they may
have developed a cancer cure by now.
John Beard one hundred years ago understood how enzymes related to cancer
and was the pioneer of stem cell theory though he didn't even realize it at
the time and was curing cancers back then. Modern medicine is finally taking
note of him and continuing his research.
Some other links who talk about Beard:
http://www.cancerdecisions.com/062602.html
http://www.thecureforheartdisease.com/owen/CancerCure.htm
http://www.dr-gonzalez.com/treatment_txt.htm
http://www.alkalizeforhealth.net/Lenzymes.htm
"Doug Freese" <[email hidden]> wrote in message
news:[email hidden]...
|
|
| The world spends a bazillion dollars a year on cancer research and we
| still don't know the cause. Are you suggesting you know the cause?
| Please, praytell, yell it from the roof tops, there is a Pulitzer Prize
| awaiting you.
|
| -DF
|
|
