Altern Med Rev. 2000 Aug;5(4):334-46. Related Articles, Links
Scientific basis for the therapeutic use of Withania somnifera
(ashwagandha): a review.
Mishra LC, Singh BB, Dagenais S.
Los Angeles College of Chiropractic (LACC), 16200 E Amber Valley Dr.,
Whittier, CA 90609-1166. [email hidden]
OBJECTIVE: The objective of this paper is to review the literature
regarding Withania somnifera (ashwagandha, WS) a commonly used herb in
Ayurvedic medicine. Specifically, the literature was reviewed for
articles pertaining to chemical properties, therapeutic benefits, and
toxicity. DESIGN: This review is in a narrative format and consists of
all publications relevant to ashwagandha that were identified by the
authors through a systematic search of major computerized medical
databases; no statistical pooling of results or evaluation of the
quality of the studies was performed due to the widely different
methods employed by each study. RESULTS: Studies indicate ashwagandha
possesses anti-inflammatory, antitumor, antistress, antioxidant,
immunomodulatory, hemopoietic, and rejuvenating properties. It also
appears to exert a positive influence on the endocrine,
cardiopulmonary, and central nervous systems. The mechanisms of action
for these properties are not fully understood. Toxicity studies reveal
that ashwagandha appears to be a safe compound. CONCLUSION: Preliminary
studies have found various constituents of ashwagandha exhibit a
variety of therapeutic effects with little or no associated toxicity.
These results are very encouraging and indicate this herb should be
studied more extensively to confirm these results and reveal other
potential therapeutic effects. Clinical trials using ashwagandha for a
variety of conditions should also be conducted.
Publication Types:
Review
Review, Tutorial
PMID: 10956379 [PubMed - indexed for MEDLINE]