Gastroenterology. 1976 Dec;71(6):1028-32. Related Articles, Links
Inhibition of intestinal iron absorption by laundry starch.
Thomas FB, Falko JM, Zuckerman K.
The pathogenesis of iron deficiency anemia associated with amylophagia
is usually attributed to dietary iron lack. However, large quantities
of starch may inhibit intestinal iron absorption. Accordingly, studies
were carried out to determine the effect of laundry starch on the
intestinal absorption of inorganic and hemoglobin iron. In vitro,
laundry starch bound 19 to 80% of the available 59FeSO4 and 34 to 68%
of the available 59Fe-hemoglobin. Binding of both forms of iron was
pH-dependent, with maximal binding at pH 7.0. In vivo, laundry starch
significantly inhibited mucosal uptake of 59FeSO4 from isolated
duodenal loops. In nonanemic rats, administration of laundry starch
(100 mg) 1 hr before a 100-mug dose of 59FeSO4 significantly decreased
the absorption of 59FeSO4, as compared to saline or low iron chow
controls (6.2 +/- 2.0 versus 14.9 +/- 2.1 and -1.8 +/- 1.7,
respectively, P less than 0.001). In anemic rats the absorption of
either a 100-mug dose of 59FeSO4 or a 500-mug dose of 59Fe-hemoglobin
was also significantly decreased by prior administration of laundry
starch. The data obtained indicated that laundry starch (1) binds
appreciable quantities of inorganic and hemoglobin iron in vitro; (2)
inhibits the mucosal uptake or inorganic iron by isolated intestinal
loops; (3) inhibits the intestinal absorption of inorganic iron in
normal nonanemic rats, and (4) blunts the compensatory increase in
inorganic and organic iron absorption in anemic rats.
PMID: 11141 [PubMed - indexed for MEDLINE]
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