General fitness, health and nutrition · Public discussion

Re: Cholesterol Advice Needed

Started by Dr. Andrew B. Chung, MD/PhD · · Last activity · 35 posts · 801 views

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General fitness, health and nutrition
Published
18 September 2004
Last activity
30 September 2004
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Dr. Andrew B. Chung, MD/PhD
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35
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  1. Alan Wright said:

    The truth of the matter may have little to do with what is currently
    widely accepted. Science is not a democratic process, and truth is
    not a matter for a vote.

    Correct.

    Quoted message said:

    I find the arguments against the established
    ideas more than credible.

    That does not mean these arguments represent the truth.

    Quoted message said:

    The financial interests which back the
    status quo are formidable, however.

    The financial interests actually back *new* drugs and *new* targets. Patents do
    expire afterall.

    Quoted message said:

    Many who argue against them
    seem to have few vested interests and do support their claims with
    extensive references in the peer-reviewed literature.

    All is not what they may seem.

    Quoted message said:

    Typically these
    are retirees since they would otherwise have suffered professionally
    to go public sooner.

    That is one way to look at it. Another way would be that these folks were
    always on the fringe and retired early because of this.

    Quoted message said:


    You might want to do some reading on the history of the whole
    cholesterol/sat fat/heart disease idea. Ravnskov's book is a quick
    and thorough read on the subject. I also enjoyed books by Enig,
    McGee, and a couple of others listed on that site.

    They all have a hard time explaining the animal models of atherosclerosis.

    Quoted message said:


    One other good cross reference on this is to look at recent books
    by aging researchers (e.g. Austad, Finch, Kirkwood) as well as studying
    some nutritional biochemistry (e.g. Stipanuk). Seems a great deal can
    be found in accordance with the idea that the lipid theory is wrong, and
    that we should be more worried about refined carbohydrates, processed
    foods, and chronic imflammatory processes. If you also do some Pubmed
    searches on research into atherogenesis, you will find a great deal going
    on in areas unrelated to cholesterol or fat intake.

    Most regard elevated serum cholesterol as a permissive condition.

    Quoted message said:

    Seems quite a few
    researchers are betting that answers to the CHD puzzle will be found
    elsewhere (and implicitly that current hypotheses are lacking).

    These folks have lost the bet with the discovery of "reverse cholesterol
    transport."

    Quoted message said:


    Personally I've adopted a restricted carbohydrate, high sat-fat
    diet over a year a go. (I eat mainly whole unprocessed foods,
    no fast food, and cook everything fresh or eat it raw.)

    Uh-oh.

    Quoted message said:

    I've
    effortlessly lost all of the excess weight I gained over 25 years,
    and have had complete relief from several long term health
    problems, one of them chronically debilitating.

    I would be concerned about hyperketonemia being behind your loss of appetite.

    Quoted message said:

    My blood sugar
    stays locked in at the levels my liver maintains, my triglycerides
    are very low, and my LDL has remained the same as it was on
    the low fat diet I was on for 20 years.

    With the weight loss, it should be lower.

    Quoted message said:

    Other measures have
    improved, and I've had an echocardiogram which showed no
    sign of disease.

    An echocardiogram won't until *after* your heart has suffered injury.

    Quoted message said:


    For now this is the choice I am making, though I'm keeping
    my eye on the scientific literature as new findings come out,
    and of course watching the impact on my own health. So far
    ignoring the established advice has been all good for me.

    May that not be your epitaph.

    Quoted message said:


    Alan

    You will be in my prayers, dear neighbor whom I love.

    Servant to the humblest person in the universe,

    Andrew

    --
    Dr. Andrew B. Chung, MD/PhD
    Board-Certified Cardiologist
    http://www.heartmdphd.com/

    **
    Who is the humblest person in the universe?
    http://makeashorterlink.com/?L26062048

    What is all this about?
    http://makeashorterlink.com/?R20632B48

    Is this spam?
    http://makeashorterlink.com/?N69721867

  2. Quoted message said:
    Quoted message said:

    Seems quite a few
    researchers are betting that answers to the CHD puzzle will be found
    elsewhere (and implicitly that current hypotheses are lacking).

    These folks have lost the bet with the discovery of "reverse


    cholesterol

    Quoted message said:

    transport."

    What do you exactly mean by "reverse cholesterol transport"? HDL and
    atherogenic ratio?

    (Please, I do not expect detailed answer, but some link would be
    helpful.)

    Mirek

  3. Quoted message said:
    Quoted message said:

    Seems quite a few
    researchers are betting that answers to the CHD puzzle will be found
    elsewhere (and implicitly that current hypotheses are lacking).

    These folks have lost the bet with the discovery of "reverse


    cholesterol

    Quoted message said:

    transport."

    BTW, as you probably really mean the role of HDL and TC/HDL ratio, how
    do you think they lost the bet?

    Mirek

  4. Mirek Fidler said:


    Quoted message said:
    Quoted message said:

    Seems quite a few
    researchers are betting that answers to the CHD puzzle will be found
    elsewhere (and implicitly that current hypotheses are lacking).

    These folks have lost the bet with the discovery of "reverse


    cholesterol

    Quoted message said:

    transport."

    BTW, as you probably really mean the role of HDL and TC/HDL ratio, how
    do you think they lost the bet?

    http://makeashorterlink.com/?L2A913059

    Quoted message said:

    Mirek

    YOu remain in my prayers, dear Mirek whom I love.

    Servant to the humblest person in the universe,

    Andrew

    --
    Dr. Andrew B. Chung, MD/PhD
    Board-Certified Cardiologist
    http://www.heartmdphd.com/

    **
    Who is the humblest person in the universe?
    http://makeashorterlink.com/?L26062048

    What is all this about?
    http://makeashorterlink.com/?R20632B48

    Is this spam?
    http://makeashorterlink.com/?N69721867

  5. Mirek Fidler said:


    Quoted message said:
    Quoted message said:

    Seems quite a few
    researchers are betting that answers to the CHD puzzle will be found
    elsewhere (and implicitly that current hypotheses are lacking).

    These folks have lost the bet with the discovery of "reverse


    cholesterol

    Quoted message said:

    transport."

    What do you exactly mean by "reverse cholesterol transport"?

    http://makeashorterlink.com/?L2A913059

    Quoted message said:

    HDL and
    atherogenic ratio?

    Not quite.

    Quoted message said:

    (Please, I do not expect detailed answer, but some link would be
    helpful.)

    (You've got it)

    Quoted message said:

    Mirek

    You remain in my prayers, dear Mirek whom I love.

    Servant to the humblest person in the universe,

    Andrew

    --
    Dr. Andrew B. Chung, MD/PhD
    Board-Certified Cardiologist
    http://www.heartmdphd.com/

    **
    Who is the humblest person in the universe?
    http://makeashorterlink.com/?L26062048

    What is all this about?
    http://makeashorterlink.com/?R20632B48

    Is this spam?
    http://makeashorterlink.com/?N69721867

  6. Quoted message said:
    Quoted message said:

    What do you exactly mean by "reverse cholesterol transport"?

    http://makeashorterlink.com/?L2A913059

    I gess it is not the most informative link, but interesting anyway.

    I just hope these drugs will be available when I will need them🙂

    Mirek

  7. "Dr. Andrew B. Chung, MD/PhD" <[email hidden]> píse v diskusním
    príspevku news:[email hidden]...

    Quoted message said:
    Mirek Fidler said:


    Quoted message said:

    > Seems quite a few
    > researchers are betting that answers to the CHD puzzle will be


    found

    Quoted message said:
    Quoted message said:
    Quoted message said:

    > elsewhere (and implicitly that current hypotheses are lacking).
    >

    These folks have lost the bet with the discovery of "reverse


    cholesterol

    Quoted message said:

    transport."

    BTW, as you probably really mean the role of HDL and TC/HDL ratio,


    how

    Quoted message said:
    Quoted message said:

    do you think they lost the bet?

    http://makeashorterlink.com/?L2A913059

    Sorry, Andrew, but I do not understand what exactly do you mean. This
    link is about drug, not about lipid theory.

    This drug is able to raise HDL and it is also able to remove plague. Did
    you want to say that this drug demonstrates that low HDL causes CAD? Or
    what?

    Mirek

  8. Mirek Fidler said:

    "Dr. Andrew B. Chung, MD/PhD" <[email hidden]> píse v diskusním
    príspevku news:[email hidden]...

    Quoted message said:
    Mirek Fidler said:


    > > Seems quite a few
    > > researchers are betting that answers to the CHD puzzle will be


    found

    Quoted message said:
    Quoted message said:

    > > elsewhere (and implicitly that current hypotheses are lacking).
    > >
    >
    > These folks have lost the bet with the discovery of "reverse
    cholesterol
    > transport."

    BTW, as you probably really mean the role of HDL and TC/HDL ratio,


    how

    Quoted message said:
    Quoted message said:

    do you think they lost the bet?

    http://makeashorterlink.com/?L2A913059

    Sorry, Andrew, but I do not understand what exactly do you mean. This
    link is about drug, not about lipid theory.

    The existence of such a "drug" and its properties supports the theory of
    "reverse cholesterol transport."

    Quoted message said:


    This drug is able to raise HDL and it is also able to remove plague. Did
    you want to say that this drug demonstrates that low HDL causes CAD?

    No.

    Quoted message said:

    Or
    what?

    See above.

    Quoted message said:


    Mirek

    You remain in my prayers, dear Mirek whom I love.

    Servant to the humblest person in the universe,

    Andrew

    --
    Dr. Andrew B. Chung, MD/PhD
    Board-Certified Cardiologist
    http://www.heartmdphd.com/

    **
    Who is the humblest person in the universe?
    http://makeashorterlink.com/?L26062048

    What is all this about?
    http://makeashorterlink.com/?R20632B48

    Is this spam?
    http://makeashorterlink.com/?N69721867

  9. Quoted message said:
    Quoted message said:

    Sorry, Andrew, but I do not understand what exactly do you mean.


    This

    Quoted message said:
    Quoted message said:

    link is about drug, not about lipid theory.

    The existence of such a "drug" and its properties supports the theory


    of

    Quoted message said:

    "reverse cholesterol transport."

    OK, so we have reverse cholesterol transport. Good to know, but one
    would expect it based on Framingham study.

    How does it makes scientists doubting significance of TC levels on heart
    disease wrong? I think it equivalently makes them right.

    Mirek

  10. Mirek Fidler said:


    Quoted message said:
    Quoted message said:

    Sorry, Andrew, but I do not understand what exactly do you mean.


    This

    Quoted message said:
    Quoted message said:

    link is about drug, not about lipid theory.

    The existence of such a "drug" and its properties supports the theory


    of

    Quoted message said:

    "reverse cholesterol transport."

    OK, so we have reverse cholesterol transport. Good to know, but one
    would expect it based on Framingham study.

    The Framingham Heart Study was an epidemiological study. Such studies
    rarely if ever shed light on the underlying mechanism of an observed
    phenomenon.

    Quoted message said:

    How does it makes scientists doubting significance of TC levels on heart
    disease wrong?

    Those opposed to the "cholesterol theory of vascular disease" have
    generally proposed mechanisms that are independent of cholesterol.
    "Reverse cholesterol transport" is a mechanism of vascular disease
    reversal that firmly entrenches the role of cholesterol in the
    pathophysiology of this disease.

    Quoted message said:

    I think it equivalently makes them right.

    You are entitled to hold unfounded opinions.

    Quoted message said:

    Mirek

    You remain in my prayers, dear Mirek whom I love.

    May God bless you today.

    Servant to the humblest person in the universe,

    Andrew

    --
    Dr. Andrew B. Chung, MD/PhD
    Board-Certified Cardiologist
    http://www.heartmdphd.com/

    **
    Who is the humblest person in the universe?
    http://makeashorterlink.com/?L26062048

    What is all this about?
    http://makeashorterlink.com/?R20632B48

    Is this spam?
    http://makeashorterlink.com/?N69721867

  11. Quoted message said:
    Quoted message said:

    How does it makes scientists doubting significance of TC levels on


    heart

    Quoted message said:
    Quoted message said:

    disease wrong?

    Those opposed to the "cholesterol theory of vascular disease" have
    generally proposed mechanisms that are independent of cholesterol.
    "Reverse cholesterol transport" is a mechanism of vascular disease
    reversal that firmly entrenches the role of cholesterol in the
    pathophysiology of this disease.

    Good and reasonable answer.

    Anyway, just because drug that is _supposed_ to perform reverse
    cholesterol transport decreases plague does not neccessary imply that
    LDL levels alone are causative to creation of this plague. Permisive
    condition - perhaps. But as long as there are people with high LDL, low
    HDL and no CAD, things seem to be more complicated than simple
    cholesterol balance.

    Mirek

  12. "Mirek Fidler" <[email hidden]> wrote in message news:<[email hidden]>...

    Quoted message said:
    Quoted message said:
    Quoted message said:

    How does it makes scientists doubting significance of TC levels on


    heart

    Quoted message said:
    Quoted message said:

    disease wrong?

    Those opposed to the "cholesterol theory of vascular disease" have
    generally proposed mechanisms that are independent of cholesterol.
    "Reverse cholesterol transport" is a mechanism of vascular disease
    reversal that firmly entrenches the role of cholesterol in the
    pathophysiology of this disease.

    Good and reasonable answer.

    Anyway, just because drug that is _supposed_ to perform reverse
    cholesterol transport decreases plague does not neccessary imply that
    LDL levels alone are causative to creation of this plague.

    Those who subscribe to the "cholesterol theory of vascular disease"
    are not claiming that LDL levels *alone* cause the disease but rather
    that it is an important risk factor that should be lowered if one of
    the goals is prevention (either primary or secondary).

    Quoted message said:

    Permisive
    condition - perhaps. But as long as there are people with high LDL, low
    HDL and no CAD, things seem to be more complicated than simple
    cholesterol balance.

    The problem is that short of a autopsy we do not have a good way of
    definitively saying that someone has *no CAD*. And, indeed autopsies
    of young men who have died in combat leads us to believe the there is
    some degree of CAD in *everyone* with high LDL and low HDL.

    Quoted message said:

    Mirek

    You remain in my prayers, dear Mirek whom I love.

    May God bless you on this Lord's day.

    Servant to the humblest person in the universe,

    Andrew

    --
    Dr. Andrew B. Chung, MD/PhD
    Board-Certified Cardiologist
    http://www.heartmdphd.com/

    **
    Who is the humblest person in the universe?
    http://makeashorterlink.com/?L26062048

    What is all this about?
    http://makeashorterlink.com/?R20632B48

    Is this spam?
    http://makeashorterlink.com/?N69721867

  13. "Dr. Andrew B. Chung, MD/PhD" <[email hidden]> wrote in message
    news:1095481853.MT2h3ZpthOLOAGBqrEtPZA@teranews...

    Quoted message said:
    Alan Wright said:

    The truth of the matter may have little to do with what is currently
    widely accepted. Science is not a democratic process, and truth is
    not a matter for a vote.

    Correct.

    Quoted message said:

    I find the arguments against the established
    ideas more than credible.

    That does not mean these arguments represent the truth.

    Nor does it mean they are not. But I am qualified to judge
    their merits, especially when it comes to the mathematical
    sleight of hand employed in interpreting statistical results.

    Quoted message said:
    Quoted message said:

    The financial interests which back the
    status quo are formidable, however.

    The financial interests actually back *new* drugs and *new* targets.


    Patents do

    Quoted message said:

    expire afterall.

    Let's then hope that we eventually get new drugs that do something
    helpful, rather than a nightmare like statins and predecessors.

    Quoted message said:
    Quoted message said:

    Many who argue against them
    seem to have few vested interests and do support their claims with
    extensive references in the peer-reviewed literature.

    All is not what they may seem.

    Perhaps, but I often run down the references and look at raw
    data myself. I also focus on papers or books which do provide
    extensive references to the peer-reviewed literature.

    Quoted message said:
    Quoted message said:

    Typically these
    are retirees since they would otherwise have suffered professionally
    to go public sooner.

    That is one way to look at it. Another way would be that these folks were
    always on the fringe and retired early because of this.

    Irrelevant. Does not change the data, nor my personal results.

    Quoted message said:
    Quoted message said:


    You might want to do some reading on the history of the whole
    cholesterol/sat fat/heart disease idea. Ravnskov's book is a quick
    and thorough read on the subject. I also enjoyed books by Enig,
    McGee, and a couple of others listed on that site.

    They all have a hard time explaining the animal models of atherosclerosis.

    Not at all. The subject is well treated in the literature I've been exposed
    to.
    And of course animal models are not in general directly relevant or
    predictive
    for humans. Until results with animals are actually shown to be reproducible
    in humans, it cannot be assumed that they will.

    Quoted message said:
    Quoted message said:

    One other good cross reference on this is to look at recent books
    by aging researchers (e.g. Austad, Finch, Kirkwood) as well as studying
    some nutritional biochemistry (e.g. Stipanuk). Seems a great deal can
    be found in accordance with the idea that the lipid theory is wrong, and
    that we should be more worried about refined carbohydrates, processed
    foods, and chronic imflammatory processes. If you also do some Pubmed
    searches on research into atherogenesis, you will find a great deal


    going

    Quoted message said:
    Quoted message said:

    on in areas unrelated to cholesterol or fat intake.

    Most regard elevated serum cholesterol as a permissive condition.

    As distinct from a causative factor. It is irrational to attempt to defeat a
    normal and essential biochemical condition simply because it is permissive
    of a potential disease process with a separate cause, especially when the
    methods are exceedingly crude and on the whole ineffective, and in fact
    promote a wide range of other disease processes. Studies show that
    cholesterol lowering is a bad idea for almost everyone.

    Quoted message said:
    Quoted message said:

    Seems quite a few
    researchers are betting that answers to the CHD puzzle will be found
    elsewhere (and implicitly that current hypotheses are lacking).

    These folks have lost the bet with the discovery of "reverse cholesterol
    transport."

    Just another questionable way to attack symptoms when instead the
    cause should be prevented.

    Quoted message said:
    Quoted message said:

    Personally I've adopted a restricted carbohydrate, high sat-fat
    diet over a year a go. (I eat mainly whole unprocessed foods,
    no fast food, and cook everything fresh or eat it raw.)

    Uh-oh.

    Not! Best decision I ever made relative to current quality of life
    improvement.
    Try not to be so confined to old-school and cardiocentric thinking. I do
    note
    that since you cannot get past the rather primitive superstitions your were
    taught
    as a child, you may well have similar trouble accepting scientific data that
    conflict
    with your current medical indoctrination.

    Quoted message said:
    Quoted message said:

    I've
    effortlessly lost all of the excess weight I gained over 25 years,
    and have had complete relief from several long term health
    problems, one of them chronically debilitating.

    I would be concerned about hyperketonemia being behind your loss of


    appetite.

    Not even a remote possibility. I have not needed to achieve ketosis for
    quite
    a long long time (if I ever did). My appetite is great, but non carbohydrate
    rich
    foods do not cause me to gain weight. You ought to bone up on how these
    diets are done and what they achieve past the initial rapid weight loss
    phases.
    Now if you want to argue that my exceptionally stable and low blood sugar
    levels (achieved via almost constant gluconeogenesis) are harmful then show
    me the research. Note that high blood sugar levels have much better
    correlation
    with cardiovascular disease that any level of any cholesterol fraction.

    Quoted message said:
    Quoted message said:

    My blood sugar
    stays locked in at the levels my liver maintains, my triglycerides
    are very low, and my LDL has remained the same as it was on
    the low fat diet I was on for 20 years.

    With the weight loss, it should be lower.

    It's not. But my levels have never been very high, and they have
    followed a pretty typical age-related curve.

    Quoted message said:
    Quoted message said:

    Other measures have
    improved, and I've had an echocardiogram which showed no
    sign of disease.

    An echocardiogram won't until *after* your heart has suffered injury.

    Duh! Obviously, I've suffered no injury to date. Until I see at
    least some inkling that I have, I see no reason to alter my course.

    Quoted message said:
    Quoted message said:

    For now this is the choice I am making, though I'm keeping
    my eye on the scientific literature as new findings come out,
    and of course watching the impact on my own health. So far
    ignoring the established advice has been all good for me.

    May that not be your epitaph.

    Time will tell, and for now I place my bets on nutritional biochemistry
    and other science over cardiology, as the latter has been a complete
    and utter failure for all those in my extended family that have had such
    involvement. None of the drugs, surgeries, or devices has done anything
    to extend or improve quality of life. I will try a different path until new
    data comes out that can change my mind.

    Alan

  14. In article <[email hidden]>,

    (Dr. Andrew B. Chung said:

    And, indeed autopsies
    of young men who have died in combat leads us to believe the there is
    some degree of CAD in *everyone* with high LDL and low HDL.

    At my last checkup and review of my stress-echo my cardiologist stated
    that plaque build up on the order of up to 40 and 50% of the arterial
    cross section are quite common and come and go over time. If this is an
    accurate observation, then perhaps the military autopsies merely showed
    instances of the ebb and flow rather than the foundations for a
    continuous build up over a lifetime.

  15. Quoted message said:

    The problem is that short of a autopsy we do not have a good way of
    definitively saying that someone has *no CAD*. And, indeed autopsies
    of young men who have died in combat leads us to believe the there is
    some degree of CAD in *everyone* with high LDL and low HDL.

    As is *some* degree of CAD in *everyone* with high HDL and low LDL....

    Mirek

  16. Mirek Fidler said:


    Quoted message said:

    The problem is that short of a autopsy we do not have a good way of
    definitively saying that someone has *no CAD*. And, indeed autopsies
    of young men who have died in combat leads us to believe the there is
    some degree of CAD in *everyone* with high LDL and low HDL.

    As is *some* degree of CAD in *everyone* with high HDL and low LDL....

    The latter folks have no CAD on autopsy.

    Quoted message said:

    Mirek

    You remain in my prayers, dear Mirek whom I love.

    Servant to the humblest person in the universe,

    Andrew

    --
    Dr. Andrew B. Chung, MD/PhD
    Board-Certified Cardiologist
    http://www.heartmdphd.com/

    **
    Who is the humblest person in the universe?
    http://makeashorterlink.com/?L26062048

    What is all this about?
    http://makeashorterlink.com/?R20632B48

    Is this spam?
    http://makeashorterlink.com/?N69721867

  17. Owen Lowe said:


    In article <[email hidden]>,

    (Dr. Andrew B. Chung said:

    And, indeed autopsies
    of young men who have died in combat leads us to believe the there is
    some degree of CAD in *everyone* with high LDL and low HDL.

    At my last checkup and review of my stress-echo my cardiologist stated
    that plaque build up on the order of up to 40 and 50% of the arterial
    cross section are quite common and come and go over time.

    I might believe such a conversation taking place after an angiogram but
    not after a stress-echo which is not a test that can quantify the degree
    of plaque build-up.

    Quoted message said:

    If this is an
    accurate observation,

    It is not.

    Quoted message said:

    then perhaps the military autopsies merely showed
    instances of the ebb and flow rather than the foundations for a
    continuous build up over a lifetime.

    That would not explain the pristinely clean coronary arteries of those
    young men with low LDL and high HDL.

    Servant to the humblest person in the universe,

    Andrew

    --
    Dr. Andrew B. Chung, MD/PhD
    Board-Certified Cardiologist
    http://www.heartmdphd.com/

    **
    Who is the humblest person in the universe?
    http://makeashorterlink.com/?L26062048

    What is all this about?
    http://makeashorterlink.com/?R20632B48

    Is this spam?
    http://makeashorterlink.com/?N69721867

  18. Alan Wright said:


    "Dr. Andrew B. Chung, MD/PhD" <[email hidden]> wrote in message
    news:1095481853.MT2h3ZpthOLOAGBqrEtPZA@teranews...

    Quoted message said:
    Alan Wright said:

    The truth of the matter may have little to do with what is currently
    widely accepted. Science is not a democratic process, and truth is
    not a matter for a vote.

    Correct.

    Quoted message said:

    I find the arguments against the established
    ideas more than credible.

    That does not mean these arguments represent the truth.

    Nor does it mean they are not.

    However, I discern that thay do not represent the truth.

    Quoted message said:

    But I am qualified to judge
    their merits, especially when it comes to the mathematical
    sleight of hand employed in interpreting statistical results.

    I would suggest you look at the data. You can start with Framingham.

    Quoted message said:
    Quoted message said:
    Quoted message said:

    The financial interests which back the
    status quo are formidable, however.

    The financial interests actually back *new* drugs and *new* targets.


    Patents do

    Quoted message said:

    expire afterall.

    Let's then hope that we eventually get new drugs that do something
    helpful, rather than a nightmare like statins and predecessors.

    Most folks on statins are not having nightmares with it.

    Quoted message said:
    Quoted message said:
    Quoted message said:

    Many who argue against them
    seem to have few vested interests and do support their claims with
    extensive references in the peer-reviewed literature.

    All is not what they may seem.

    Perhaps, but I often run down the references and look at raw
    data myself. I also focus on papers or books which do provide
    extensive references to the peer-reviewed literature.

    Then you should conclude that LDL should be lowered and HDL should be
    raised if the goal is to prevent atherosclerosis.

    Quoted message said:
    Quoted message said:
    Quoted message said:

    Typically these
    are retirees since they would otherwise have suffered professionally
    to go public sooner.

    That is one way to look at it. Another way would be that these folks were
    always on the fringe and retired early because of this.

    Irrelevant. Does not change the data, nor my personal results.

    The same could be said for your current view.

    Quoted message said:
    Quoted message said:
    Quoted message said:


    You might want to do some reading on the history of the whole
    cholesterol/sat fat/heart disease idea. Ravnskov's book is a quick
    and thorough read on the subject. I also enjoyed books by Enig,
    McGee, and a couple of others listed on that site.

    They all have a hard time explaining the animal models of atherosclerosis.

    Not at all. The subject is well treated in the literature I've been exposed
    to.

    It seems by your next statement, your exposure has been "kill-filtered."

    Quoted message said:

    And of course animal models are not in general directly relevant or
    predictive
    for humans. Until results with animals are actually shown to be reproducible
    in humans, it cannot be assumed that they will.

    The disease that is reproduced in the animal models occurs under
    conditions that humans are currently exposed to in the societies with
    high rates of atherosclerotic disease.

    Quoted message said:
    Quoted message said:
    Quoted message said:

    One other good cross reference on this is to look at recent books
    by aging researchers (e.g. Austad, Finch, Kirkwood) as well as studying
    some nutritional biochemistry (e.g. Stipanuk). Seems a great deal can
    be found in accordance with the idea that the lipid theory is wrong, and
    that we should be more worried about refined carbohydrates, processed
    foods, and chronic imflammatory processes. If you also do some Pubmed
    searches on research into atherogenesis, you will find a great deal


    going

    Quoted message said:
    Quoted message said:

    on in areas unrelated to cholesterol or fat intake.

    Most regard elevated serum cholesterol as a permissive condition.

    As distinct from a causative factor. It is irrational to attempt to defeat a
    normal and essential biochemical condition simply because it is permissive
    of a potential disease process with a separate cause, especially when the
    methods are exceedingly crude and on the whole ineffective, and in fact
    promote a wide range of other disease processes. Studies show that
    cholesterol lowering is a bad idea for almost everyone.

    You are welcome to cite the studies. I would be more than happy to give
    you my professional comments on each.

    Quoted message said:
    Quoted message said:
    Quoted message said:

    Seems quite a few
    researchers are betting that answers to the CHD puzzle will be found
    elsewhere (and implicitly that current hypotheses are lacking).

    These folks have lost the bet with the discovery of "reverse cholesterol
    transport."

    Just another questionable way to attack symptoms when instead the
    cause should be prevented.

    This is a observed phenomenon rather than a treatment.

    Quoted message said:
    Quoted message said:
    Quoted message said:

    Personally I've adopted a restricted carbohydrate, high sat-fat
    diet over a year a go. (I eat mainly whole unprocessed foods,
    no fast food, and cook everything fresh or eat it raw.)

    Uh-oh.

    Not! Best decision I ever made relative to current quality of life
    improvement.
    Try not to be so confined to old-school and cardiocentric thinking.

    The mission here is to prevent catastrophic cardiovascular events.

    Quoted message said:

    I do
    note
    that since you cannot get past the rather primitive superstitions your were
    taught
    as a child, you may well have similar trouble accepting scientific data that
    conflict
    with your current medical indoctrination.

    Sorry my being openly Christian distracts you.

    Quoted message said:
    Quoted message said:
    Quoted message said:

    I've
    effortlessly lost all of the excess weight I gained over 25 years,
    and have had complete relief from several long term health
    problems, one of them chronically debilitating.

    I would be concerned about hyperketonemia being behind your loss of


    appetite.

    Not even a remote possibility. I have not needed to achieve ketosis for
    quite
    a long long time (if I ever did). My appetite is great, but non carbohydrate
    rich
    foods do not cause me to gain weight.

    They would if you ate more of them.

    Quoted message said:

    You ought to bone up on how these
    diets are done and what they achieve past the initial rapid weight loss
    phases.

    It is doubtful that my reviewing your diet methodologies would reveal
    another explanation for your loss of appetite.

    Quoted message said:

    Now if you want to argue that my exceptionally stable and low blood sugar
    levels (achieved via almost constant gluconeogenesis) are harmful then show
    me the research.

    Why would I want to do that?

    My concern is your possibly having hyperketonemia because of inadequate
    dietary carbohydrates. Your body stores carbohydrates in the form of
    glycogen because carbohydrates are an essential macronutrient.

    Quoted message said:

    Note that high blood sugar levels have much better
    correlation
    with cardiovascular disease that any level of any cholesterol fraction.

    It seems you are confusing diabetes with high blood sugar.

    Quoted message said:
    Quoted message said:
    Quoted message said:

    My blood sugar
    stays locked in at the levels my liver maintains, my triglycerides
    are very low, and my LDL has remained the same as it was on
    the low fat diet I was on for 20 years.

    With the weight loss, it should be lower.

    It's not.

    Which is why I would be concerned.

    Quoted message said:

    But my levels have never been very high, and they have
    followed a pretty typical age-related curve.

    Such age-related curves are better explained as a weight-related curve.

    Quoted message said:
    Quoted message said:
    Quoted message said:

    Other measures have
    improved, and I've had an echocardiogram which showed no
    sign of disease.

    An echocardiogram won't until *after* your heart has suffered injury.

    Duh!

    There can be severe atherosclerotic disease *before* there is injury.

    President Clinton would be a timely illustrative case in point.

    He was also low-carbing.

    Quoted message said:

    Obviously, I've suffered no injury to date.

    Presumably by not obviously to me.

    Quoted message said:

    Until I see at
    least some inkling that I have, I see no reason to alter my course.

    That was apparently President Clinton's philosophy on this topic.

    Quoted message said:
    Quoted message said:
    Quoted message said:

    For now this is the choice I am making, though I'm keeping
    my eye on the scientific literature as new findings come out,
    and of course watching the impact on my own health. So far
    ignoring the established advice has been all good for me.

    May that not be your epitaph.

    Time will tell, and for now I place my bets on nutritional biochemistry
    and other science over cardiology, as the latter has been a complete
    and utter failure for all those in my extended family that have had such
    involvement. None of the drugs, surgeries, or devices has done anything
    to extend or improve quality of life.

    The lifestyle changes and medications work better when done *before*
    there is a cardiovascular "event."

    Quoted message said:

    I will try a different path until new
    data comes out that can change my mind.

    Your informed choice for your health and your soul.

    Quoted message said:

    Alan

    You remain in my prayers, dear Alan whom I love.

    May Christ heal you as only He can.

    Servant to the humblest person in the universe,

    Andrew

    --
    Dr. Andrew B. Chung, MD/PhD
    Board-Certified Cardiologist
    http://www.heartmdphd.com/

    **
    Who is the humblest person in the universe?
    http://makeashorterlink.com/?L26062048

    What is all this about?
    http://makeashorterlink.com/?R20632B48

    Is this spam?
    http://makeashorterlink.com/?N69721867

  19. Howard said:
    Dr. Andrew B. Chung said:

    There can be severe atherosclerotic disease *before* there is injury.

    President Clinton would be a timely illustrative case in point.

    He was also low-carbing.

    Big Macs and fries are *not* low-carb.

    Correct.

    Quoted message said:

    Clinton was low-carbing maybe
    3 months before the discovery of his heart problems, which were caused
    by a lifetime of junk food, not by his more recent (moderately)
    low-carb diet.

    There is such an entity as accelerated coronary atherosclerosis (CAD). We
    can induce laboratory animals to go from *no* CAD to *severe* CAD in a
    matter of 3-6 months. We do this with a high lipid (low carb and low
    protein) diet.

    Servant to the humblest person in the universe,

    Andrew

    --
    Dr. Andrew B. Chung, MD/PhD
    Board-Certified Cardiologist
    http://www.heartmdphd.com/

    **
    Who is the humblest person in the universe?
    http://makeashorterlink.com/?L26062048

    What is all this about?
    http://makeashorterlink.com/?R20632B48

    Is this spam?
    http://makeashorterlink.com/?N69721867

  20. Howard said:

    Big Macs and fries are *not* low-carb. Clinton was low-carbing maybe
    3 months before the discovery of his heart problems, which were caused
    by a lifetime of junk food, not by his more recent (moderately)
    low-carb diet.

    Your proof of this is.........?

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