Occup Environ Med. 2004 Jan;61(1):82-5. Links
Total body iron overload in welder's siderosis.
Doherty MJ, Healy M, Richardson SG, Fisher NC.
Department of Respiratory Medicine, Dudley Group of Hospitals, West Midlands,
UK. Department of Haematology, Dudley Group of Hospitals, West Midlands, UK.
Department of Gastroenterology, Dudley Group of Hospitals, West Midlands, UK.
Welder's siderosis occurs as a consequence of the inhalation of iron dust. The
iron overload of welder's siderosis is usually considered to be confined to the
lungs. Here we present three proven cases of welder's siderosis associated with
evidence of increased total systemic iron stores, as evidenced by increased
serum ferritin levels. Multiple investigations including molecular genotyping
for the common mutations found in genetic haemochromatosis failed to prove this
was due to haemochromatosis, nor was there any evidence of any other recognised
cause of systemic iron overload. Thus the systemic iron overload described
seems likely to be due to either occupational exposure, an uncharacterised
genetic haemochromatosis, or a combination of both.
PMID: 14691279 [PubMed - in process]
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