Food Chem Toxicol. 2004 Mar;42(3):459-64. Related Articles, Links
Effect of an acute dose of ethanol on lipid peroxidation in rats: action of vitamin E.
Jordao AA Jr, Chiarello PG, Arantes MR, Meirelles MS, Vannucchi H.
Postgraduation in Food Science, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Av.
Bandeirantes, 3900, 14049-900, Ribeirao Preto-SP, Brazil.
Free radical generation is an important step in the pathogenesis of ethanol-associated liver injury.
Administration of ethanol induces an increase in lipid peroxidation both by enhancing the production
of oxygen reactive species and by decreasing the levels of endogenous antioxidants. This work
focuses on the generation of free radicals provoked by an acute ethanol dose in rats, and the role
of different dietary levels of vitamin E. The objective of this investigation was to study the
effect of three different dietary levels of vitamin E (deficient, control and supplemented with 20
times higher levels) on plasma and liver lipid peroxidation (assayed by TBARS), vitamin E in plasma
and liver, and hepatic glutathione concentration, in rats receiving the different diets. The animals
were submitted to an acute dose of ethanol (5 g/kg body weight) administered by gavage at the end of
an experimental 4 week period and were sacrificed at 0, 2, 4, 8 and 24 h after ethanol
administration. Dietary vitamin E caused a dose-dependent increase in liver and plasma concentration
of the vitamin, but ethanol administration decreased hepatic vitamin E in all groups. TBARS
concentrations were higher in liver of rats that received the deficient diet, independent of
ethanol, however, liver TBARS concentrations were low in control and supplemented groups, but
increased with ethanol ingestion. Glutathione levels were lowered by ethanol administration in all
groups, in different times, but recovered to this original level in 24 h time. In conclusion,
vitamin E deficiency alone induces liver lipid peroxidation in rats, acute administration of ethanol
affect vitamin E and GSH level and maintenance of adequate or higher vitamin E levels acts as a
protective factor against free radical generation.
PMID: 14871588 [PubMed - in process]
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