<<snip>>
This result confirm the vitamin
E to be an important factor of the normal process of nerve regeneration
<<snip>>
: Arch Ital Anat Embriol 1990 Apr-Jun;95(2):155-65 Related Articles,
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Effect of vitamin E-deficiency on regeneration of the sciatic nerve.
Cecchini T, Cuppini R, Ciaroni S, Del Grande P.
Istituto di Scienze Morfologiche, Universita di Urbino, Italy.
The regeneration of the sciatic nerve fibres was studied in both normal
and
vitamin E-deficient rats at 30 and 60 days after crush. The vitamin E
is
involved in one of the most important mechanisms of protection against
peroxidation of plasma membrane lipids; the plasma membrane plays
certainly a
role in nerve regeneration. Both the diameter and the total number of
myelinated nerve fibres was calculated at different times. The number
of
myelinated fibres in the undenervated deficient animals was lower than
that
found in the undenervated normals animals. Following the nerve crush,
in normal
animals after two months the number of myelinated fibres exceeded the
number
found in undenervated normal animals, whereas in the deficient rat
nerves it
was significantly lower than in the corresponding controls and moreover
it did
not even reach the number found in the nerves of undenervated deficient
rats.
Finally, the caliber distribution of myelinated fibres in undenervated
and
denervated deficient rats shows a relative percent increase in the
number of
greatest axons and a decrease in smaller axons. This result confirm the
vitamin
E to be an important factor of the normal process of nerve
regeneration.
PMID: 2078094 [PubMed - indexed for MEDLINE]
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