vasodilators and angina

Martin Braff said:

Dipyridamole is a vasodilator that seems to cause angina
while nitroglycerin is a vasodilator that relieves angina.

Could anyone explain the reason for the differing effects
on angina?

Dipyridamole's action as a vasodilator depends on an intact
(and healthy) endothelium. When there is coronary disease,
dipyridamole can cause either coronary "steal" and/or
"spasm" leading to regional ischemia.

Nitroglycerin is an endothelium-independent vasodilator
so that vasodilation will always occur. However, many
believe that it is the preload reduction that decreases
the workload of the heart that plays as important a
role in nitroglycerin's relieving angina as dilating
coronary arteries.

Quoted message said:

Thanks,

Marty

You are welcome, Marty.

Servant to the humblest person in the universe,

Andrew

--
Dr. Andrew B. Chung, MD/PhD
Board-Certified Cardiologist
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