Ultrasound Med Biol. 2003 Dec;29(12):1799-1803. Links
Ultrasound-mediated release of iron from ferritin.
Morrissey JM, Taylor KD, Gilman SD.
Cavalier Discovery Incorporated, Mason, OH, USA
We investigated the release of iron from ferritin in aqueous solutions exposed to high-frequency
ultrasound (US). Our data suggests that superoxide produced as a result of ultrasonic cavitation
acts as a reducing agent, enabling the release of iron from ferritin. We also found that the release
of ferritin iron during US exposure is enhanced by the addition of 5-hydroxy-1,4-naphthoquinone. We
hypothesize that this quinone is ultrasonically transformed into a semiquinone radical capable of
directly and indirectly reducing Fe(3+) in ferritin to soluble Fe(2+). Our proposed mechanism for
the release of iron from ferritin adds new insight to the synergistic effect of quinone-containing
cancer drugs with US. (E-mail: [email hidden])
PMID: 14698347 [PubMed - as supplied by publisher]
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