Ultrasound Med Biol. 2003 Dec;29(12):1799-1803. Links
Ultrasound-mediated release of iron from ferritin.
Morrissey JM, Taylor KD, Gilman SD.
Cavalier Discovery Incorporated, Mason, OH, USA
We investigated the release of iron from ferritin in aqueous solutions exposed
to high-frequency ultrasound (US). Our data suggests that superoxide produced
as a result of ultrasonic cavitation acts as a reducing agent, enabling the
release of iron from ferritin. We also found that the release of ferritin iron
during US exposure is enhanced by the addition of 5-hydroxy-1,4-naphthoquinone.
We hypothesize that this quinone is ultrasonically transformed into a
semiquinone radical capable of directly and indirectly reducing Fe(3+) in
ferritin to soluble Fe(2+). Our proposed mechanism for the release of iron from
ferritin adds new insight to the synergistic effect of quinone-containing
cancer drugs with US. (E-mail: [email hidden])
PMID: 14698347 [PubMed - as supplied by publisher]
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