Clin Chem Lab Med. 2004 Feb;42(2):154-8. Links
Antioxidants in patients with hyperthyroidism.
Mayer L, Romic Z, Skreb F, Bacic-Vrca V, Cepelak I, Zanic-
Grubisic T, Kirin M.
Department of Laboratory Medicine, Dubrava University
Hospital, Zagreb, Croatia. [email hidden]
Hyperthyroidism is a hypermetabolic state accompanied by
increased oxygen utilization, increased production of
reactive oxygen species and consequentially measurable
changes in antioxidative factors. Therefore, the activities
of whole blood glutathione peroxidase (GPx) and erythrocyte
superoxide dismutase (SOD), total antioxidant status (TAS)
in serum and erythrocytes, and serum urate and transferrrin
concentrations were determined in 70 women: 14 with newly
diagnosed Graves' disease (group A); 28 with hyperthyroidism
on therapy with methimazole (group B, divided into two
subgroups, B1 and B2) and 28 healthy women (group C). In
comparison with control group C, GPx activity was
significantly decreased in all patient groups (p < 0.05),
whereas SOD activity was significantly decreased in group A
(p < .01) and significantly increased in group B (p < 0.01).
In comparison with the control group, serum TAS activity was
significantly decreased in group A, and erythrocyte TAS
activity in all patient groups. Study results suggest that
the impaired antioxidative factor balance leads to the
development and presence of oxidative stress in women with
hyperthyroidism. The severity of these alterations,
considered contradictory by some authors, appears to depend
on the use of therapy.
PMID: 15061353 [PubMed - in process]
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