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high plasma ferritin levels are detrimental in acute ischemic stroke
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Curr Med Chem. 2007;14(8):857-874.Iron, Oxidative Stress and Early
Neurological Deterioration in Ischemic Stroke.Carbonell T, Rama R.
Department of Physiology, University of Barcelona. Avda. Diagonal,
645, E-08028 Barcelona, Spain. [email hidden].
Ischemic stroke is characterized by the disruption of cerebral blood
flow, which produces a central core of dead neurons surrounded by a
penumbra of damaged but partially functional neurons. Many factors are
associated with such brain injury, including excitotoxicity and free
radicals. Recent clinical studies have shown that high plasma ferritin
levels are detrimental in acute ischemic stroke. As an iron-storage
protein, ferritin can act both as a scavenger and as a donor of free
iron, which is a source of hydroxyl radicals. Following disruption of
the blood-brain barrier, the ferritin and the free iron that have
accumulated in endothelial cells in brain capillaries, together with
plasma ferritin, can enter the penumbra. Iron-dependent oxidative
stress in the penumbra can lead to necrosis and further neurological
deterioration following ischemic stroke. An excess of iron should be
considered pathological in the ischemic brain. Therapeutic strategies
for ischemic stroke should attempt to restore brain function within
the penumbra. Consequently, the iron content of systemic stores should
be measured, and anti-oxidant treatment should be considered when it
is excessive.
PMID: 17430141 [PubMed - as supplied by publisher]Who loves ya.
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