Chem Biol Interact. 2007 May 18; [Epub ahead of print]
Attenuation of plasma dyslipidemia and oxidative damage by dietary
caloric restriction in streptozotocin-induced diabetic rats.Ugochukwu
NH, Figgers CL.
Department of Chemistry, Florida A&M University, Tallahassee, FL
32307, United States.
Oxidative stress has been proposed as the pathogenic mechanism linking
insulin resistance with endothelial dysfunction during diabetes. The
present study investigated the attenuation of plasma dyslipidemia and
oxidative damage by caloric restriction in experimental diabetes.
Forty male Wistar rats were divided into ad libitum and calorie-
restricted groups. The calorie-restricted group was subjected to 30%
caloric restriction for 63 days before induction of diabetes to 50% of
both groups. Caloric restriction significantly (p<0.01) reduced the
body weights, reactive oxygen species (ROS), catalase, total
cholesterol levels and non-significantly reduced SOD activities in non-
diabetic and diabetic rats. Caloric restriction was also found to
improve blood glucose levels, glycated hemoglobin, malondialdehyde,
triglyceride, oxidized glutathione and reduced glutathione levels and
significantly (p<0.05) increased GPx and GR activities in the
experimental animals. The non-diabetic rats fed ad libitum had the
most significant increases in body weight which could be due to
dyslipidemia. These results indicate that dietary caloric restriction
attenuates the oxidative damage and dyslipidemia exacerbated during
diabetes as evidenced by the significant reduction in their body
weights, ROS, total cholesterol levels and the increases in GPx
activity and redox status.
PMID: 17580083 [PubMed - as supplied by publisher]
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