Selected biochemical parameters of blood serum in soldiers committing
self-mutilation.
Florkowski A, Gruszczynski W, Wawrzyniak Z
Mil Med. 2001 May ; 166(5): 375-7
OBJECTIVE: This project attempts to establish a possible link between
selected biochemical parameters (cholesterol and triglyceride
concentrations and levels of malonyl dialdehyde and superoxide
dismutase) in soldiers with autoaggressive behaviors. MATERIALS AND
METHODS: The study involved 33 soldiers treated for self-aggressive
behavior from July 1, 1998, to June 30, 1999. Average patient age was
20.7 years. The control group consisted of 21 soldiers hospitalized for
mental disturbances but not showing autoaggressive tendencies. Total
cholesterol and activity of platelets, considering the generation of
free radicals and triglyceride concentration levels, were determined in
the blood serum of members of both groups. RESULTS: The results
indicate significantly lower concentrations of total cholesterol in the
serum of soldiers showing self-aggressive behaviors. Also, increased
concentrations of malonyl dialdehyde in blood platelets and decreased
superoxide dismutase activity were found in individuals prone to
autoaggression. CONCLUSION: The results suggest that the dysfunction of
oxidation-reduction processes in brain tissue leads to excessive
generation of free radicals, which can cause brain cell damage and
disturb metabolic processes, resulting in mental disturbances that may
constitute a background for self-aggressive behavior. The decreased
activity of superoxide dismutase is a major factor in the observed
oxidation-reduction disturbances.
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