This would give a bit of credence to the .. iron .. BEING the ..target
IN .. skin whitening .. as argued .. http://tinyurl.com/2scmzx ..
since gallic acid is an effective chelator of iron.
Biol Pharm Bull. 2007 Jun;30(6):1052-5. Links
Antimelanogenic and antioxidant properties of gallic Acid.Kim YJ.
Department of Cosmetology, Pusan Women's College.
To find novel skin-whitening agents, the melanogenesis inhibitory
action of gallic acid (GA) was investigated. In this current study,
the effects of GA on mushroom tyrosinase, tyrosinase inhibitory
activity, and melanin content were assessed in B16 melanoma cells (B16
cells). Results indicated that GA has a strong antityrosinase activity
(IC(50)=3.59x10(-6) M). Furthermore, data on murine tyrosinase
activity and melanin biosynthesis revealed that GA effectively
suppressed murine tyrosinase action and the amount of melanin. To
investigate the relation between GA's inhibition of melanogenesis and
antioxidant activity, the effect of GA on reactive species (RS)
generation and the reduced glutathione (GSH)/oxidized glutathione
(GSSG) ratio in were determined in B16 cells. Results indicated that
GA effectively down-regulated the RS generation and enhanced the GSH/
GSSG ratio. Based on these results, I propose that GA exerts
antimelanogenic activity coupled with antioxidant properties by
suppressing RS generation and maintaining a higher GSH/GSSG ratio.
PMID: 17541153 [PubMed - in process]
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk