The sequence of the amino acids leads to the specific folding of the protein. If that is so and Both
high heat and/or pH can denature or unfold proteins Then
It would suggest that at first the informational sequence of the amino acids that lead to the most
thermally stable fold would be selected in a heat cycle. Those that lead to thermally unstable
folding patterns would be destroyed in the heat cycle.
Thus the aa conformation or the aa information that was selected would lead to that which folds to
the shape that survives unfolding, denaturing.
So at this point sequence of aa's that lead to thermally stable folds are the only aa sequences that
will survive the environment. That suggests that protein sequence is based on thermal stability at
this point. (Later if two variants both have thermal stability then the one most advantageous in
other ways, would be selected)
And the same case could be made for nucleotide structure. That coding that best supports thermal
stability will survive that day. The rest will be destroyed or denatured. Thus the nucleotide coding
is that which leads to thermal stability at this stage.
Comment?