Quoted message said:Subject: Selective bloodletting for severe ulcerative colitis
From: [email hidden] (doe)
Date: 6/30/2004 7:43 PM Mountain Daylight Time
Message-id: <[email hidden]>
I wonder what the results .. here .. are .. ? And I wonder
how you .. become .. one of the .. selected ..
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Scand J Gastroenterol. 2004 May;39(5):416-7. Related
Articles, Links
Selective bloodletting for severe ulcerative colitis.
Premehand P, Takeuchi K, Bjarnason I.
Dept. of Gastroenterology, King's College Hospital, London,
UK. [email hidden]
PMID: 15180176 [PubMed - in process]
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Went to the University Library and pulled the article ..
This is a snip ..
Seems to compare .. apheresis TO .. bloodletting ..
Same result .. different methods and expense ..
<<snip>> With current insight into the pathogenesis of
various 'inflammatory' diseases , and the involvement of
circulating cells, cytokines and other cell-cell signalling
molecules, a possible rationale for bloodletting emerges,
i.e. removal of pro-inflammatory cells or substances thereby
interrupting a viscous cycle whereby effector molecules
perpetuate inflammation. The Japanese experience in
ulcerative colitiis , if confirmed in controlled trials ,
has the potential to alter our approach to the treatment of
severe exacerbation of ulcerative colitis, thus obviating
the need for surgery, which is associated with significant
morbidity. While the precise mechansim of benefit of this
treatmemt is not fully understood , the apheresis systems
are also showing promise in Crohn disease . We suggest that
this may herald a new therapeutic approach whereby speciific
constituents of blood are removed rather than neurtralized
with antibodies , which are unavoidably associated with
tolerance and side effects. <<snip>>
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