Quoted message said:FINDINGS MAY SUPPORT SOY-DEMENTIA CORRELATION IN MALES
(c) 08/06/03 - Ian Williams Goddard
In April 2000, Lon White and others reported a dose-dependent positive
correlation between tofu consumption and brain atrophy in a large
sample of men over several decades. [1]
White et al: http://www.jacn.org/cgi/content/full/19/2/242
Posted this elsewhere (CR means caloric restriction):
IAN: Here's a rebuttle to White et al followed by their
responce: http://www.jacn.org/cgi/content/full/19/4/467
As I've noted, laboratory findings are also relevent. The
soy phytoestrogen genistein inhibits DNA synthesis in rat
cerebral cortex and suppresses a range of neurotrophic
(neuroprotective) factor functions. An important example:
J Neurochem (Oct 1995): "The ability of the neurotrophic
factors to suppress glutamate toxicity and glutamate-induced
peroxide accumulation [in hippocampal neurons] was attenuated
by the tyrosine kinase inhibitor genistein, indicating the
requirement for tyrosine phosphorylation in the neuro-
protective signal transduction mechanism."
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7561872&dopt=Abstract
"Attenuated" of course means "reduced." Genistein reduced a
critical antiaging function. In fact, it's well-known that the
chemical class to which genistein is a member, tyrosine kinase
inhibitors, interfere with neurotrophic (neuroprotective)
factors as a class trait. If CR is neuroprotective because it
raises neurotrophic factors, the same logic suggests that soy
could be neurotoxic for inducing the opposite (even if only in
males). In short, the known effects of soy phytochemicals point
to a prediction of brain atrophy. In my view, that adds weight
to the soy-dementia correlation reported by White et al.
"To lengthen thy life, lessen thy meals." Ben Franklin