http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=448892&dopt=Abstract
Studies of amygdalin (laetrile) toxicity in rodents.
Khandekar JD, Edelman H.
Amygdalin (laetrile), given to Fischer 344 rats in doses of 250, 500, and
750 mg/kg intraperitoneally daily for five days, caused mortalities of 30.8%
44.1%, and 56.8%, respectively. The mode of death and the elevated serum
cyanide levels in the dying animals strongly suggested cyanide poisoning as
the cause of death. These findings seriously question the use of amygdalin
in clinical medicine under any circumstances.
In theory (upper and lower limits in rodents)
250*80=20,000mg
750*80=60,000mg (average weight of man)
20 grammes per day of pure amygdalin should cause 30.8% mortality
60 grammes per day of pure amygdalin should cause 56.8% mortality
http://www.worldwithoutcancer.org.uk/mono.html
Acute Toxicity Through I.V. Application:
The minimum lethal dose was not achieved in dosages up to 15,000 mg/kg/B.W.
(or 120,000mg total dosages). The general symptoms were slight arterial
hypotension and fleeting adipsia, which appeared after the minimum toxic
dosage of 3,750 mg/kg/B.W.
Subacute Intravenous Toxicity:
There were no undesirable effects up to daily dosages of 1,000 mg/kg/B.W.
for eight weeks.
Chronic Intravenous Toxicity:
Dosages up to 15 mg/kg/B.W. five days per week, for six consecutive months,
did not cause clinical or histopathological alterations in necropsy studies
of the exposed dogs.
Acute Oral Toxicity:
The minimal lethal dose was 14,318 mg/kg/B.W. and the minimum toxic dose was
400 mg/kg/B.W. The symptoms that were observed were apathy, anorexia,
adipsia, and loss of hair. These symptoms disappeared in less than 48 hours
in the dogs in which AMYGDALIN was discontinued. The dog that received the
minimum lethal dosage developed convulsions and typical cyanide poisoning
shock which evolved into coma and death by cardiac arrest.
Oral Toxicity:
By calculation, some authors suggested as the minimum lethal dosage 2,000 to
2,500 mg/kg/B.W.
All these findings coincide with that mentioned by Otto Jacobsen in 1887,
Davidson in 1944, and Dr. Dean Burk (National Cancer Institute of the USA)
in 1968. "AMYGDALIN is impressively atoxic (non-toxic) from the
pharmacological point of view," and that "Non-hydrolyzed AMYGDALIN is less
toxic than glucose." On the other hand, our studies proved that KEMDALIN in
dosages of 100 to 120 mg/kg/B.W. (unusual dosage for humans) by intravenous
application corresponds to a dosage of AMYGDALIN 30 to 40 times less than
the minimum toxic dosage in dogs and that KEMDALIN in dosages of 20 to 40
mg/kg/B.W. orally, used in humans, is some 10 to 20 times less than the
minimum toxic dosage, orally, in dogs.
Note :-
All these findings coincide with that mentioned by Otto Jacobsen in 1887,
Davidson in 1944, and Dr. Dean Burk (National Cancer Institute of the USA)
in 1968. "AMYGDALIN is impressively atoxic (non-toxic) from the
pharmacological point of view,"
i.e. a complete 'porky pie' laetrile is toxic
Anth
