Re: dietary squalene

Yes, I agree - I should clarify my position.

If a mechanism has been established, such as free radical damage to
cell constituents, then markers of oxidative stress are at least good
indirect evidence. In this case, however, it is not clear exactly what
the point of the experiment is. If the researchers want to say that
one should avoid foods high in squalene because this will have the
effect of raising cholesterol, they should say it. If they do, it will
be clear that they are totally unaware of the evidence that has built
up over the past 15 years or so which demonstrates that only oxidized
cholesterol is unhealthy, but at least there will be an ostensible
point to what they spent plenty of time and money doing.

On 13 May 2005 21:26:17 -0700, "montygram" <[email hidden]>

Quoted message said:

be clear that they are totally unaware of the evidence that has built
up over the past 15 years or so which demonstrates that only oxidized
cholesterol is unhealthy, but at least there will be an ostensible
point to what they spent plenty of time and money doing.

Cholesterol oxidation happen when the molecules are sirculating in the
body for an extended period, because receptors that should capture the
molecules for uptake into cells for degradation, don't work or work
too slow.

In such cases increasing cholesterol synthesis is a bad idea, because
it will in turn build up the amount of oxidiced cholesterol too.