General fitness, health and nutrition · Public discussion

Questions about TB/Latencies?

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General fitness, health and nutrition
Published
31 May 2005
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1 June 2005
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  1. Hi,

    I have following thoughts/confusions/questions:-

    1. Suppose a person is exposed to TB bacterias & gets some acute
    reactions from these but didn't get it as full active stage. So he
    aquires latent TB infections with out any symptoms. I think it is due
    to inability of immunity to handle all the bacterias on its exposure at
    that time. Our defence system then opt for 2nd option--arrest/encapsule
    these bacterias as latent stage to stop their multiplication & spread
    or starve these in capsule by arresting or wait for the right
    oppurtunity by improving the immunity/defence power to handle or kill
    them. Is it right?

    Now suppose that person got his immunity/defence power suitably
    improved after some time which can then become capable to handle those
    hidden/dormant or encapsuled bacterias in latency OR weakens his
    immunity.

    What will happen? On improved immunity--will those bacterias be
    resurfaced/directly exposed to immune agents to kill the bacterias as a
    "direction towards cure" but presenting an apparent impression of
    active stage OR not? On weakened immunity--will these infecting agents
    be resurfaced, multiply & spread as a "direction towards spread of
    disease" OR not? We can also think similarily for cancer.

    In short; can an impression of active stage/spread after a
    latency/tumor formation be a direction towards cure on improved
    immunity AND a direction of increase the infection/disease on weakening
    the immunity/defence power?

    2. Whether excess/low gastric acid can effect the effectiveness of TB
    durgs? Suppose a person under this TB tratment, if lives in a place
    with hard water/alkaline water supply OR take other foods which can
    raise his gastric pH, can experiance lesser effects of TB medicines or
    not? In short, I want to know whether imbalances in digetive pH can
    effect the effectiveness/absorption of TB medicines or not?

    3. Does immune defence system withhold iron or other nutrition to
    starve those bacterials in their latent stage (also cancer cells in
    their tumor stage)

    4. Can low imbalances in digestive pHs also encourage intestinal mucus
    blocks resulting into low medicines absorption?

    I shall be thankful if you can reply/discuss these questions.

  2. "M. tuberculosis was the most restricted in growth at pH 6.0, and all
    of this growth required elevated levels of Mg2+...These results
    demonstrate that M. tuberculosis is unique among the mycobacteria in
    its extreme sensitivity to acid and indicate that M. tuberculosis must
    acquire sufficient Mg2+ in order to grow in a mildly acidic environment

    such as within the phagosome of macrophages.
    http://iai.asm.org/cgi/content/abst...pe2=tf_ipsecsha "
    Does it indicate awnser to my sceond question?

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