General fitness, health and nutrition · Public discussion

Promising results for antiangiogenic compounds

Started by Bill Brown · · Last activity · 3 posts · 666 views

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General fitness, health and nutrition
Published
25 September 2003
Last activity
27 September 2003
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Bill Brown
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  1. Hi,

    Some exciting news has just been published today about an antiangiogenic compound for cancer
    patients. Aeterna Laboratories, a Canadian Biotech, released its phase III clinical trial results on
    renal carcinoma. For a specific subgroup of patients, their product, the Neovastat, increased the
    median survival time by 109% for patients suffering of clear cell renal carcinoma with 1 metastasis
    in the lung. These patients more than doubled their life expectancy from 12.6 months for the placebo
    group to 26.3% for the Neovastat group.

    This subpopulation represents some of the "healthier" patients in this study. It seems to confirm
    the paradigm that the earlier a patient is treated with anti-angiogenic compounds, the better his or
    her chances for a positive outcome.

    Angiogenesis control has been confirmed again to be a promising strategy to fight cancer. While
    waiting for more pharmaceutical results, there is one dietary supplement on the market with a
    similar mechanism of action, it's called CarTCell.

    Faithfully yours,

    Bill

  2. [email hidden] (Bill Brown) wrote in :"]news:[email hidden]:

    Quoted message said:

    Hi,

    Some exciting news has just been published today about an antiangiogenic compound for cancer
    patients. Aeterna Laboratories, a Canadian Biotech, released its phase III clinical trial results
    on renal carcinoma. For a specific subgroup of patients, their product, the Neovastat, increased
    the median survival time by 109% for patients suffering of clear cell renal carcinoma with 1
    metastasis in the lung. These patients more than doubled their life expectancy from 12.6 months
    for the placebo group to 26.3% for the Neovastat group.

    This subpopulation represents some of the "healthier" patients in this study. It seems to confirm
    the paradigm that the earlier a patient is treated with anti-angiogenic compounds, the better his
    or her chances for a positive outcome.

    Angiogenesis control has been confirmed again to be a promising strategy to fight cancer. While
    waiting for more pharmaceutical results, there is one dietary supplement on the market with a
    similar mechanism of action, it's called CarTCell.

    Faithfully yours,

    Bill

    Please explain how:
    1. failure at top line analysis is "promising", and
    2. results in a small, statistically insignificant sub-group (N=
    3) are meaningful.

  3. [email hidden] (Bill Brown) wrote in message
    news:<[email hidden]>...

    Quoted message said:

    Hi,

    Quoted message said:

    Angiogenesis control has been confirmed again to be a promising


    strategy to fight cancer. While waiting for more pharmaceutical results, there is one dietary
    supplement on the market with a similar mechanism of action, it's called CarTCell.

    Faithfully yours,

    Bill

    Turmeric, the spice is about 40% curcumins, which are a very effective angiogenesis inhibitor.
    Probably a lot cheaper than a boutique supplement.

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