prinary and secondary insulin response

John38 wrote in message ...

Quoted message said:

Hi group

I'm a t2. i have had it mentioned to me that perhaps I have a almost non-existent primary insulin
response and a (better) secondary. What are the differences, and what triggers primary, what
triggers secondary?

cheers

First phase insulin is insulin thought to have been pre-manufactured and somehow stored ready
for instant use. Second phase insulin is insulin that is manufactured in response to elevated
blood sugar.

Both T1 and T2 lose 1st phase insulin err. . .well, first, e.g.

medscape.com410819 5Open ↗

". . .Lack of first-phase insulin release, an excellent predictor of both types of diabetes, . . ."

For a bit more on 1st and 2nd phase insulin, see

childrenwithdiabetes.comf.htmOpen ↗

.". . . . It is thought that this almost immediate release (1st phase insulin) is due to release of
insulin that was previously manufactured, and was being stored in the beta cell. . .

". . . . .It is thought that this delayed release is due to release of insulin (2nd phase insulin)
that is manufactured in the beta cell after the blood sugar starts to rise. . ."

Both are triggered by a rise in bG. I think 2nd phase doesn't kick in till you hit bG = 110 mg/dL

Regards
Old Al

On Wed, 28 Jan 2004 12:40:09 -0500, oldal4865 <[email hidden]>

Quoted message said:

.". . . . It is thought that this almost immediate release (1st phase insulin) is due to release
of insulin that was previously manufactured, and was being stored in the beta cell. . .

so it either isn't made, or it can't be released? or not being made at an appropiate rate?

Quoted message said:

Both are triggered by a rise in bG. I think 2nd phase doesn't kick in till you hit bG = 110 mg/dL

cheers Old Al
--
John38 - t2 or LADA? : dx@11/2003 : fbg @DX=13.6mmol/l : fbg now=6.7mmol/l glimepiride 6mg :
aspirin 100mg : fish oil : low carb : exercise BGs gradually coming into control : Weekly
avg=9.21mmol/l : BMI=24

John38 wrote in message ... .

Quoted message said:

so it either isn't made, or it can't be released? or not being made at an appropiate rate?

cheers Old Al

AFAIK, not made at all.

However, I don't recall a specific quote to that effect.

Regards
Old Al

Al,

I've read somewhere that first phase insulin is released as soon as you start to chew or even, in
some cases, smell food, which is what keeps the blood sugar rock solid steady in people who are
truly normal.

-- Jenny - Low Carbing for 4 years. At goal for weight. Type 2 diabetes, hba1c 5.2. Cut the carbs to
respond to my email address!

Low carb facts and figures, my weight-loss photos, tips, recipes, strategies for dealing with
diabetes and more at geocities.comjenny the beanOpen ↗

Looking for help controlling your blood sugar? Visit alt-support-alt-support-Open ↗
diabetes.org/Newly%20Diagnosed.htm

"oldal4865" <[email hidden]> wrote in message -"]news:[email hidden]-
berlin.de...

Quoted message said:

John38 wrote in message ...

Quoted message said:

Hi group

I'm a t2. i have had it mentioned to me that perhaps I have a almost non-existent primary insulin
response and a (better) secondary. What are the differences, and what triggers primary, what
triggers secondary?

cheers

First phase insulin is insulin thought to have been pre-manufactured

and

Quoted message said:

somehow stored ready for instant use. Second phase insulin is insulin that is manufactured in
response to elevated blood sugar.

Both T1 and T2 lose 1st phase insulin err. . .well, first, e.g.

medscape.com410819 5Open ↗

". . .Lack of first-phase insulin release, an excellent predictor of both types of
diabetes, . . ."

For a bit more on 1st and 2nd phase insulin, see

childrenwithdiabetes.comf.htmOpen ↗

.". . . . It is thought that this almost immediate release (1st phase
insulin) is due to release of insulin that was previously manufactured,

and

Quoted message said:

was being stored in the beta cell. . .

". . . . .It is thought that this delayed release is due to release of insulin (2nd phase insulin)
that is manufactured in the beta cell after

the

Quoted message said:

blood sugar starts to rise. . ."

Both are triggered by a rise in bG. I think 2nd phase doesn't kick in

till

Quoted message said:

you hit bG = 110 mg/dL

Regards
Old Al