Although some individuals here have referred to NICO as a
non existent condition, these licensed, medical practitionrs
not only disagree, but they have documented what they
consider is scientific proof. I offer this information
because it is in my own personal best interest to accept and
believe that they know what they are talking about and that
this information could be helpful to others.
Includes maxillofacial osteonecrosis (NICO), avascular
necrosis of the mandibular condyle, and necrotizing
otitis externa.
1. Shaber EP, Krol AJ. Trigeminal neuralgia -- a new
treatment concept. Oral Surg 1980; 49:286-293, 1980.
2. Mathis BJ, Oatis GW, Grisius RJ. Jaw bone cavities
associated with facial pain syndromes: case reports.
Milit Med 1981; 146:719-723.
3. Jiao X, Meng Q. [The influence of pathologic bone cavity
of jaw bone on the etiopathology of trigeminal
neuralgia.] Acta Acad Med Sichuan 1981;
4:243-247.
5. Parisier SC, Lucente FE, Som PM, et al. Nuclear scanning
in necrotizing progressive "malignant external otitis.:
Laryngoscope 1982; 92:1016-1019.
6. [censored] M, Xiwei J, Qingrong I, Sanyou Z. [A study of the
relation between the various trigger zones of idiopathic
trigeminal neuralgia and jaw bone cavities.] Acta Acad
Med Sichuan 1982; 13:233-238.
7. [censored] M, Jiao X, Meng Q, et al. [Localization method in
the diagnosis of the pathological jaw bone cavity.] Acta
Acad Med Sichuan 1982; 13:341-344.
8. Mendelson DS, Som PM, Mendelson MH, Parisier SC.
Malignant external otitis: the role of computed
tomography and radionuclides in evaluation. Radiology
1983; 149:745-749
9. Grecko VE, Puzin MN. [Odontogenic trigeminal neuralgia]
Zh Nevropathol Psikhiatr 1984; 84(11):1655-1658.
10. Noyek AM, Kirsch JC, Greyson ND, et al. The clinical
significance of radionuclide bone and gallium scanning
in osteomyelitis of the head and neck. Laryngoscope
1984; 94:1-21.
11. Roberts AM, Person P, Chandran NB, Hori JM. Further
observations on dental parameters of trigeminal and
atypical facial neuralgias. Oral Surg 1984; 58:121-129.
12. Strashun AM, Nejatheim M, Goldsmith SJ. Malignant
external otitis: early scintigraphic detection.
Radiology 1984; 150:541-545.
13. Balm AJM, Tiwari RM, deRijcke TBM. Osteomyelitis in the
head and neck. J Laryngol Otol 1985; 99:1059-1065.
14. Strauss M, Kaufman RA, Baum S. Osteomyelitis of the head
and neck: sequential radionuclide scanning in diagnosis
and therapy. Laryngoscope 1985; 95:81-84.
15. Gherini SG, Brackmann DE, Bradley WG. Magnetic resonance
imaging and computerized tomography in malignant
external otitis. Laryngoscope 1986;
16:542-548.
17. Ratner EJ, Langer B, Evins ML. Alveolar cavitational
osteopathosis -- manifestations of an infectious process
and its implication in the causation of chronic pain. J
Periodontol 1986; 57:593-603.
18. Rubin J, Yu VL. Malignant external otitis: insights into
pathogenesis, clinical manifestations, diagnosis, and
therapy. Am J Med 1988; 85:391-398.
19. Benecke JE Jr. Management of osteomyelitis of the skull
base. Laryngoscope 1989; 99:1220-1223.
20. Chandler JF. Malignant external otitis and osteomyelitis
of the base of the skull. Am J Otol 1989; 10:108-110.
21. Lanigan DT, Hey JH, West RA. Aseptic necrosis following
maxillary osteotomies: report of 36 cases. J Oral
Maxillofac Surg 1990; 48:142-156.
22. Rubin J, Curtin HD, Yu VL, Kamerer DB. Malignant
external otitis: utility of CT in diagnosis and follow-
up. Radiology 1990; 174:391-394.
23. Segall RO, Del Rio CE. Cavitational bone defect: a
diagnostic challenge. J Endo 1991; 17:396-400.
24. Uri N, Gips S, Front A, Meyer SW, et al. Quantitative
bone and 67Ga scintigraphy in the differentiation of
necrotizing external otitis from severe external otitis.
Arch Otolaryngol Head neck Surg 1991; 117:623-626.
25. Bouquot JE, Roberts AM, Person P, Christian J. NICO (neuralgia-
inducing cavitational osteonecrosis): osteomyelitis in
224 jawbone samples from patients with facial
neuralgias. Oral Surg Oral Med Oral Pathol 1992;
26:307-319.
27. Epstein JS, Ganz WI, Lizak M, Grobman L, et al. Indium-111-
labeled leukocyte scintigraphy in evaluating head
and neck infections. Ann Otol Rhinol Laryngol 1992;
101:961-968.
28. Malone DG, O'Boynick PL, Ziegler DK, et al.
Osteomyelitis of the skull base. Neurosurgery 1992;
30:426-431.
29. McMahon RE, Adams W, Spolnik K. Diagnostic anesthesia
for referred trigeminal pain, Part I. Compendium Cont
Educ Dent 1992; 11:870-881.
30. McMahon RE, Adams W, Spolnik K. Diagnostic anesthesia
for referred trigeminal pain, Part II. Compendium Cont
Educ Dent 1992; 11: 980-997.
31. O'Mara, RE. Scintigraphy of the facial skeleton. Oral
Maxillofac Surg Clin N Amer 1992; 4:51-___.
32. Chuong R, Piper MA. Avascular necrosis of the mandibular
condyle: pathogenesis and concepts of management. Oral
Surg Oral Med Oral Pathol 1993; 75:428-432.
33. Hasso AN, Brown KD. Use of gadolinium chelate in MR
imaging of lesions of the extracranial head and neck. J
Magn Reson Imaging 1993; 3:247-263.
34. Shankland WE. Osteocavitational lesions (Ratner bone
cavities): frequently misdiagnosed as trigeminal neuralgia-
a case report. J Craniomand Pract 1993; 11:232-234.
35. Hardoff R, Gips S, Uri N, Front A, Tamir A.
Semiquantitative skull planar and SPECT bone
scintigraphy in diabetic patients: differentiation of
necrotizing (malignant) external otitis from severe
external otitis. J Nucl Med 1994; 35:411-415.
36. Mandel ID. Dental quackery: a retrospective view. J Amer
Dent Assoc 1994; 125:153-160.
37. Readleaf MI, Angeli SI, McCabe BF. Indium 111-labeled
white blood cell scintigraphy as an unreliable indicator
of malignant external otitis resolution. Ann Otol Rhinol
Laryngol 1994; 103:444-448.
38. Wormald PJ. Surgical management of benign necrotizing
otitis externa. J Laryngol Otol 1994; 108:101-105.
39. Bouquot JE, Christian J. Long-term effects of jawbone
curettage on the pain of facial neuralgia; treatment
results in neuralgia-inducing cavitational
osteonecrosis. J Oral Maxillofac Surg 1995; 53:387-397.
40. Brown RS, Hinderstein B, Reynolds DC, et al. Using
anesthetic localization to diagnose oral and dental
pain. JADA 1995; 126: 633-641.
41. Chuong R, Piper MA, Boland TJ. Osteonecrosis of the
mandibular condyle, pathophysiology and core
decompression. Oral Surg Oral Med Oral Pathol Oral
Radiol Endod 1995; 79:539-545.
42. McMahon RE, Griep J, Marfurt CP, et al. Local anesthetic
effects in the presence of chronic
osteomyelitis/necrosis of the mandible: implications for
localizing the etiologic sites of referred trigeminal
pain. J Craniomand Pract 1995; 13:212-226.
43. Seabold JE, Simonson TM, Weber PC, et al. Cranial
osteomyelitis: diagnosis and follow-up with In-111 white
blood cell and Tc-99m methylene diphosphonate bone
SPECT, CT, and MR imaging. Radiology 1995; 196:779-788.
44. Shankland WE. Craniofacial pain syndromes that mimic
temporomandibular joint disorders. Ann Acad Med
Singapore 1995; 24:104-106.
45. Brown CR. Pain management: NICO. Pract Perio Aesth Dent
1996; 8:916.
46. Damm DD, Fantasia JE. Recurrent severe mandibular pain.
Gen Dent 1996; Mar/Apr:120,171.
47. Glueck CJ, McMahon RE, Bouquot JE, et al. Thrombophilia,
hypofibrinolysis and osteonecrosis of the jaws. Oral
Surg Oral Med Oral Pathol 1996; 81:557-566.
48. Gruppo R, Glueck CJ, McMahon RE, et al. The
pathophysiology of osteonecrosis of the jaw:
anticardiolipin antibodies, thrombophilia, and
hypofibrinolysis. J Lab Clin Med 1996; 127:481-488.
49. Glueck CJ, McMahon RE, Bouquot JE, et al. Heterozygosity
for the Leiden mutation V gene, a common pathoetiology
for osteonecrosis of the jaw with thrombophilia
augmented by exogenous estrogens. J Lab Clin Med 1997;
50:540-543.
51. Glueck CJ, McMahon R, Bouquot J, et al. A preliminary
pilot study of treatment of thrombophilia and
hypofibrinolysis and amelioration of the pain of
osteonecrosis of the jaws. Oral Surg Oral Med Oral
Pathol Oral Radiol Endod 1998; 85:64-73.
52. Glueck CJ, McMahon RE, Bouquot JE, Triplett D. Exogenous
estrogens may exacerbate thrombophilia, impair bone
healing and contribute to development of chronic facial
pain. J Craniomand Pract 1998; 16:143-153.
53. Adams WR, Spolnik KJ, Bouquot JE. Maxillofacial
osteonecrosis in a patient with multiple facial pains. J
Oral Pathol Med 1999, 28:423-432.
54. Bouquot JE, LaMarche MG. Ischemic osteonecrosis under
fixed partial denture pontics: radiographic and
microscopic features in 38 patients with chronic pain. J
Pros Dent 1999; 81:148-158.
55. Larheim TA, Westesson P-L, Hicks D, Eriksson L, et al.
Osteonecrosis of the temporomandibular joint:
correlation of magnetic resonance imaging and histology.
J Oral Maxillofac Surg 1999; 57:888-898.
56. Sano T, Westesson P-L, Larheim TA, Rubin SJ, et al.
Osteoarthritis and abnormal bone marrow of the
mandibular condyle. Oral Surg Oral Med Oral Pathol Oral
Radiol Endod 1999; 87:243-252.
57. DuPont JD. Unhealed extraction sites mimicking TMJ pain.
Gen Dent 2000;
58:82-85.
59. Bouquot JE, McMahon RE. Neuropathic pain in
maxillofacial osteonecrosis (NICO). J Oral Maxillofac
Surg 2000; 58:in press.