Oxidative stress / thyroid disease

"doe" <[email hidden]> wrote in message "]news:[email hidden]...

Quoted message said:

<<snip>> oxidative stress is involved in pathomechanism of thyroid disease, e.g., Graves' disease,
goiter formation or thyroid cancer. <<snip>>

You can assume it is involved in most, if not all, of tissue induced damage. It is so broad and
basic in terms of tissue induced injury that it makes such phrases of no use. Show me an article
stating that such oxidative stress is the primary defect "causing" not just involved in such
diseases. Graves disease has an autoimmune component in which antibodies directed against the
thyroid gland causes the damage. You have thyroid stimulating immunoglobulins which bind to the TSH
receptor in the thryoid gland causesing the release of thryoid hormone. The TSH levels in
hyperthyroidism is non detectable. I have no doubt that tissue damage involving ROS are involved but
not primary in origin. Goiter formation is hypertrophy of the gland in iodine deficiency. It can be
secondary to a malfunctioning gland in which part of the gland is destroyed and the remaining
functional part becomes enlarged.

Quoted message said:

Neuroendocrinol Lett. 2003 Oct;24(5):293-303. Related Articles, Links

the protective action of

Quoted message said:

antioxidants, melatonin included, may occur during both physiological and pathological processes
in the thyroid, however, this assumption, requires further studies.

PMID: 14647000 [PubMed - in process]

Which study is more important, one in which a person implies something or one in which somebody
actually studies implications? Why wasn't his study entiled "The protective action of antioxidants,
melatonin included, in thyroid disease. "

Show me one study in which all these diseases in which oxidative stress in thought to be of primary
importance in terms of pathophysiology in which antioxidants have been proven to be of help in
preventing. Show me one biochemical reaction in which iron is not involved or oxygen is not involved
or water is not involved.

Quoted message said:

melatonin may protect against extensive oxidative damage in the course of certain thyroid disorders

I would agree with this based on personal experience, and especially for menopausal and post-
menopausal women with thyroid disorder and high oxidative damage. The autoimmune process itself
tends to generate high oxidative stress. I would add highest quality alpha lipoic acid (such as by
Solgar) to one's supplements in these conditions to also mitigate against extensive oxidative damage
in the course of certain thyroid disorders.

- CBW

healthheal.comhealthheal.comOpen ↗

SOD (Superoxide dismutase) can now be taken orally in a bioavailable form called Prozyme (or Polbax
in Sweden).

Defects in the gene influencing SOD have been implicated as a factor provoking the incidence of some
cases of familial ALS/MND. A SOD supplement may possibly prove to be extremely useful in the
treatment of both familial and sporadic (common) ALS/MND.

Researchers initially reported that even though SOD and other antioxidant enzymes are far more
powerful than vitamins and other nutrients at scavenging free radicals, they couldn't be taken
orally because they would be destroyed in the digestive tract and thus couldn't be assimilated by
the body. Recent studies published in leading medical journals report that the world's first SOD
antioxidant enzyme can be assimilated by the human body. It is now available only through a whole
food, flower pollen extract product called Prozyme. Superoxide dismutase enzymes have been extracted
from pollen and pistills of Zea mays (maize) and in two commercial products, BaxtinR and PolbaxR,
derived from the same material.

Pharmacia Allergon AB, a 50 year old Swedish pharmaceutical company, produces a tablet form of SOD
derived from flower pollen extracts. This pollen also contains a perfectly balanced combination of
other major antioxidant enzymes (glutathione, catalase) and all other nutrients (vitamins, minerals,
amino acids, flavonoids, etc.) necessary to sustain life. This makes Prozyme 10 the most powerful
aid for preventing conditions associated with free radical damage and over 10 years of clinical
trials in Europe demonstrate the safety and efficacy of this completely natural product.

Per Christer Oden, Department of Forest Genetics and Plant Physiology, Swedish University of
Agricultural Sciences, S-901 83 Ume"a, Sweden and Roland Einarsson, Pharmacia Diagnostics, S-751 82
Uppsala, Sweden.

SOD is a key component in the free radical detoxification process. SOD-enzymes have been extensively
studied during the last ten years and they are now considered present in all aerobic organisms (for
reviews see Rabinowitch and Fridovich 1983, Fridovich 1986, Asada 1988, Monk et al. 1989, Hassan and
Scandalios 1990).

The results of SOD-activity determinations were convincing.One gram of Polbax (Prozyme) will
correspond to approximately 4000 mg of CuZn-SOD.

You may be able to obtain more information about Prozyme and other pollen based products by
contacting healthheal.comhealthheal.comOpen ↗

Another possible source outside of the USA is via Gary , Singapore healthheal.comhealthheal.comOpen ↗ . They
ship POLBAX internationally. Manufacturer: Pharmacia & Upjohn Allergon AB (Sweden)

"Robert" <[email hidden]> ¦b¶l¥ó "]news:[email hidden] ¤¤¼¶¼g...

Quoted message said:

"doe" <[email hidden]> wrote in message news:20031206145202.08055.00000302@mb-
m16.aol.com...

Quoted message said:

<<snip>> oxidative stress is involved in pathomechanism of thyroid disease, e.g., Graves'
disease, goiter formation or thyroid cancer. <<snip>>

You can assume it is involved in most, if not all, of tissue induced

damage.

Quoted message said:

It is so broad and basic in terms of tissue induced injury that it makes such phrases of no use.
Show me an article stating that such oxidative stress is the primary

defect

Quoted message said:

"causing" not just involved in such diseases. Graves disease has an autoimmune component in which
antibodies directed against the thyroid gland causes the damage. You have thyroid stimulating
immunoglobulins which bind to the TSH receptor in the thryoid gland causesing the release of
thryoid hormone. The TSH levels in

hyperthyroidism

Quoted message said:

is non detectable. I have no doubt that tissue damage involving ROS are involved but not primary
in origin. Goiter formation is hypertrophy of the gland in iodine deficiency. It can be secondary
to a malfunctioning gland in which part of the gland is destroyed and the remaining functional
part becomes enlarged.

Quoted message said:

Neuroendocrinol Lett. 2003 Oct;24(5):293-303. Related Articles, Links

the protective action of

Quoted message said:

antioxidants, melatonin included, may occur during both physiological

and

Quoted message said:

Quoted message said:

pathological processes in the thyroid, however, this assumption,

requires

Quoted message said:

Quoted message said:

further studies.

PMID: 14647000 [PubMed - in process]

Which study is more important, one in which a person implies something or one in which somebody
actually studies implications? Why wasn't his study entiled "The protective action of
antioxidants, melatonin included, in thyroid disease. "

Show me one study in which all these diseases in which oxidative stress in thought to be of
primary importance in terms of pathophysiology in which antioxidants have been proven to be of
help in preventing. Show me one biochemical reaction in which iron is not involved or oxygen

is

Quoted message said:

not involved or water is not involved.