oxidative stress / chronic tonsillitis.



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Otolaryngol Head Neck Surg. 2003 Sep;129(3):265-268. Related Articles, Links

Free radicals and scavenging enzymes in chronic tonsillitis.

Kaygusuz I, Idot;lhan N, Karlidag T, Keles E, Yalcin S, cEtiner H.

OBJECTIVE: This study aimed to define the relationship between chronic tonsillitis and levels of
malondialdehyde and superoxide dismutase in free radical and antioxidant forms. It is suggested that
free oxygen radicals may play a role in chronic tonsillitis.Materials and methods One hundred twenty-
four patients were enrolled in the study. Tonsillectomy was performed via the usual dissection-snare
method. Venous blood was taken preoperatively and at 2 weeks postoperatively. Blood samples and
tonsil specimens were evaluated for malondialdehyde and superoxide dismutase analysis. RESULTS: The
levels of malondialdehyde and superoxide dismutase in plasma were compared preoperatively and
postoperatively, and there were statistically significant differences between these levels (P <
0.05). In contrast, the levels of malondialdehyde and superoxide dismutase in tonsil tissue were not
correlated with the plasma levels of malondialdehyde and superoxide dismutase in pretonsillectomy
and posttonsillectomy terms (P > 0.05). CONCLUSION: The presence of malondialdehyde and superoxide
dismutase in plasma and tonsil tissue reinforces the involvement of oxidative stress in the
pathophysiology of chronic tonsillitis.

PMID: 12958578 [PubMed - as supplied by publisher]

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