Obesity and Type 2

Mike said:

Can anyone give me a nutshell explanation of why type 2 diabetics are more prone to weight issues?
I am type 1 and have little experience with type 2. I'm in Nursing school and need some info on
this subject.

Thanks, Mike Type 1 since 76. Humalog/Lantus

Its hard to say which comes first... excess Weight contributes to insulin resistance, which causes
higher insulin production, insulin causes weight gain. Kind of a catch 22. Which started first is a
toss-up. Insulin resistance or weight gain. It appears from much of the literature that weight is
major contrubuting factor, though not the only one. Genetics also contribute.

That said, insulin resistance does not make weight gain inevitable, only harder to control.

BJ

[email hidden] (Mike) wrote in
:"]news:[email hidden]:

Quoted message said:

Can anyone give me a nutshell explanation of why type 2 diabetics are more prone to weight issues?
I am type 1 and have little experience with type 2. I'm in Nursing school and need some info on
this subject.

Insulin does more than one thing. Insulin transports glucose from the blood stream, across the cell
wall, into tissue. Insulin is also part of the hormonal control structure for metabolism.

To get type 2 diabetes, you need to have insulin resistance and a defect in insulin production or
form. The easiest, but certainly not the only, way to get insulin resistance, is to become obese.
Most obese people are not diabetic, however, because there is a tremendous over capacity to produce
insulin in the normal pancreas. They just keep pumping out insulin until it overcomes the insulin
resistance and bg levels stay in their narrow normal range. If you don't have the normal over
capacity, your bg levels rise and you are diagnosed as a diabetic.

Notice that, in either case, you are producing high levels of insulin. The level of insulin, in
relation to those of the counter regulatory hormones, has an effect on the metabolic system. Low
levels of insulin stimulate the liver to release stored glucose into the bloodstream. High
relative levels of insulin bias the energy storage pathways to store the energy from excess
glucose more in fat.

There seems to be a wide variation in the difficulty with which people lose weight. The
hyperinsulinemia associated with insulin resistance is offered by some as part of the explanation.
There are some popular weight loss schemes that are based on minimizing serum insulin excursions.

That is the smallest nutshell of which I am capable. For further information do some searching on
the terms 'metabolic syndrome' and 'syndrome x'.

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Charly Coughran [email hidden]

In article <[email hidden]>,

Mike said:

Can anyone give me a nutshell explanation of why type 2 diabetics are more prone to weight issues?
I am type 1 and have little experience with type 2. I'm in Nursing school and need some info on
this subject.

There are two main explanations which have been given; both seem to be supported.

For those who have the genetic makeup needed for insulin resistance, excess weight increases the
tendency for the insulin resistance to manifest itself.

For those who have the genetic makeup, the hormones act to increase the tendency to obesity, as well
as to bring on insulin resistance.

--
This address is for information only. I do not claim that these views are those of the Statistics
Department or of Purdue University. Herman Rubin, Department of Statistics, Purdue University
[email hidden] Phone: (765)494-6054 FAX: (765)494-0558

Overweight is a risk factor for type II diabetes, but especially weight gain around the waist. Dr.
Mirkin explains "Do you know why people who store fat primarily in their bellies are at high risk
for heart attacks and diabetes? After you eat, blood sugar levels rise. If they rise too high, they
call out huge amounts of insulin. Insulin closes arteries to cause heart attacks and acts on the
brain to make you eat more and on your liver to manufacture more fat, and on the fat cells in your
belly to store that fat.

The liver removes insulin from the bloodstream, but insulin causes fat to be deposited in the liver
which prevents the liver from removing insulin from the bloodstream, so people with fat bellies
store too much fat in their livers, which prevents the livers from removing insulin, so insulin
levels rise higher and higher to cause heart attacks, more abdominal obesity and eventually
diabetes."

drmirkin.com1127.htmlOpen ↗

[email hidden] (Mike) wrote in message news:<[email hidden]>...

Quoted message said:

Can anyone give me a nutshell explanation of why type 2 diabetics are more prone to weight issues?
I am type 1 and have little experience with type 2. I'm in Nursing school and need some info on
this subject.

Thanks, Mike Type 1 since 76. Humalog/Lantus