NF-kappa B activation / iron

As it says, iron is also needed for proper health. I posted an article in the last week or so, for
the consideration of Tom and to which he did not respond, showing research where iron was an
unexpected benefit to proper neurological activity; As I recall it was with regard to copper as a
toxic agent. Maybe Tom can look it up and comment uopon it also. But wait, he almost never comments
or expands the info posted into any meaningful larger picture, no doubt thinking his "unique" thesis
so broadly understood that it's implication is obvious .. NOT ..

Quoted message said:

Comp Hepatol. 2004 Jan 14;3 Suppl 1:S36. Links

Signaling role of iron in NF-kappa B activation in hepatic macrophages.

Xiong S, She H, Tsukamoto H.

Department of Pathology, Keck School of Medicine, University of Southern California, USA.
[email hidden]

Iron is both essential and toxic for cells and impaired iron homeostasis has been shown to cause or
potentiate various forms of liver injury. Research in our laboratory suggests that iron also plays
a pivotal role in intracellular signaling for NF-kappa B activation in hepatic macrophages (HM).
Our results showed: 1) HM from alcohol-fed rats had a increase in the nonheme iron content
accompanied by NF-kappa B activation; 2) iron chelation normalized nonheme iron concentration and
blocked enhanced NF-kappa B activation and TNF-alpha expression in these cells; 3) LPS-induced NF-
kappa B activation was also blocked by iron chelator; 4) iron directly induced TNF-alpha expression
via IKK and NF-kappa B activation in normal HM. We propose that iron acts as an independent
proinflammatory molecule via induction of the intracellular signaling for NF-kappa B activation in
HM and primes the liver for chronic inflammation and injury.

PMID: 14960188 [PubMed - as supplied by publisher]

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Who loves ya. Tom Jesus Was A Vegetarian! jesuswasavegetarian.7h.comjesuswasavegetarian.7h.comOpen ↗ Man Is A Herbivore!
pages.ivillage.commanisaherbivoreOpen ↗ DEAD PEOPLE WALKING
pages.ivillage.comdeadpeoplewalkingOpen ↗

Quoted message said:

Subject: Re: NF-kappa B activation / iron
From: [email hidden]
Date: 2/14/2004 1:20 PM Mountain Standard Time
Message-id: <[email hidden]>

As it says, iron is also needed for proper health. I posted an article in the last week or so, for
the consideration of Tom and to which he did not respond, showing research where iron was an
unexpected benefit to proper neurological activity; As I recall it was with regard to copper as a
toxic agent. Maybe Tom can look it up and comment uopon it also. But wait, he almost never comments
or expands the info posted into any meaningful larger picture, no doubt thinking his "unique"
thesis so broadly understood that it's implication is obvious .. NOT ..

Maybe you simply didn't understand my .. 'take' .. on .. your .. contributions ..?

[censored] ..

I'll spell it for ya ..

S .. H .. I .. T .. E ..

Quoted message said:

Quoted message said:

Comp Hepatol. 2004 Jan 14;3 Suppl 1:S36. Links

Signaling role of iron in NF-kappa B activation in hepatic macrophages.

Xiong S, She H, Tsukamoto H.

Department of Pathology, Keck School of Medicine, University of Southern California, USA.
[email hidden]

Iron is both essential and toxic for cells and impaired iron homeostasis has been shown to cause
or potentiate various forms of liver injury. Research in our laboratory suggests that iron also
plays a pivotal role in intracellular signaling for NF-kappa B activation in hepatic macrophages
(HM). Our results showed: 1) HM from alcohol-fed rats had a increase in the nonheme iron

content

Quoted message said:

accompanied by NF-kappa B activation; 2) iron chelation normalized nonheme

iron

Quoted message said:

concentration and blocked enhanced NF-kappa B activation and TNF-alpha expression in these cells;
3) LPS-induced NF-kappa B activation was also blocked by iron chelator; 4) iron directly induced
TNF-alpha expression via

IKK

Quoted message said:

and NF-kappa B activation in normal HM. We propose that iron acts as an independent
proinflammatory molecule via induction of the intracellular signaling for NF-kappa B activation in
HM and primes the liver for chronic inflammation and injury.

PMID: 14960188 [PubMed - as supplied by publisher]

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------

Who loves ya. Tom

Jesus Was A Vegetarian! jesuswasavegetarian.7h.comjesuswasavegetarian.7h.comOpen ↗ Man Is A Herbivore!
pages.ivillage.commanisaherbivoreOpen ↗ DEAD PEOPLE WALKING
pages.ivillage.comdeadpeoplewalkingOpen ↗

Ah, our good friend Tom can be scatological even different languages, no wait, in these days of the
net dictionaries of languages are a dime a dozen; oh drat; we will find something he knows something
about .. WE .. NEED .. ONLY PATIENCE.

[email hidden] [email hidden] [email hidden] Once upon a time, our fellow markd@toad-
net.com rambled on about "Re: NF-kappa B activation / iron." Our champion De-Medicalizing in
sci.med.nutrition retorts, thusly ...

Quoted message said:

Ah, our good friend Tom can be scatological

It is about time that you geeks started posting on a real topic.

Just my opinion. But, I am *right* as usual!