ironjustice <[email hidden]> wrote in message
"]news:[email hidden]...
Quoted message said:
ironjustice <[email hidden]> wrote in message
"]news:[email hidden]...
Quoted message said:Below is the description of the .. bullet .. what is the bullet made of
..
Quoted message said:?
Quoted message said:
Clues : Causes free radicals / rust / oxidation / reactive oxygen species .. and
it
Quoted message said:'weighs in at' .. "In all three diseases the agent is a substance with a
low
Quoted message said:molecular weight between 1000 and 10,000 daltons"
Z Rheumatol 39: 84-90 (1980)[81035511]
Chromosomal instability in collagen disease.
I. Emerit
Chromosome instability is observed in patients with collagen disease. It is due to the
presence of a chromosome-breaking agent in the serum which also induces chromosome breaks and
rearrangements in blood cultures from healthy subjects. It is not possible to say at present
whether this breakage factor is identical to that in patients with progressive systemic
sclerosis, lupus erythematosus or rheumatoid arthritis. In all three diseases the agent is a
substance with a low molecular weight between 1000 and 10,000 daltons. Since the enzyme
superoxide dismutase has an anticlastogenic protective effect, the action of the agent on
chromosomes is probably an indirect one,
namely
Quoted message said:Quoted message said:by generation of oxygen-dependent free radicals such as O2- x and OH.
MeSH Terms:
* Animal
* Arthritis, Rheumatoid/physiopathology
* Cells, Cultured
* Chromosome Aberrations*
* Collagen Diseases/physiopathology
* Human
* Lupus Erythematosus, Systemic/physiopathology
* Mice
While we wait to see if anyone can figure this out .. why don't we all
take
Quoted message said:some iron chelators .. in the meantime ..
Postepy Hig Med Dosw 2002;56(2):169-84
[Chloroquine--miscellaneous properties of the antimalarial drug.] [Article in Polish]
Jarzyna R Zaklad Regulacji Metabolizmu Instytutu Biochemii Uniwersytetu
Warszawskiego.
Quoted message said:[email hidden]
Chloroquine is a drug with over 60 years of safe clinical use in the treatment of malaria. The
multiple mechanisms of chloroquine action have appeared to be useful in the therapy of many
miscellaneous disorders well beyond its original antimalarial purposes. This paper is focused on
the application of chloroquine for the treatment of malaria, porphyria cutanea tarda, rheumatoid
arthritis, palindromic rheumatism and lupus. The possibility of the use of chloroquine in the
therapy of other disorders
such
Quoted message said:as diabetes mellitus, AIDS, hyperlipidemia, sarcoidosis, hypercalcemia,
and
Quoted message said:melanoma is reviewed. Mechanisms of action of the drug as well as side effects on metabolism are
discussed in view of recent discoveries.
Publication Types:
Review Review, tutorial PMID: 12107961, UI: 22101359
--------------------------------------------------------------------------
--
Quoted message said:----
Lupus 1996 Jun;5 Suppl 1:S59-64
The use of chloroquine and hydroxychloroquine for non-infectious
conditions
Quoted message said:other than rheumatoid arthritis or lupus: a critical review.
Wallace DJ Cedars-Sinai Medical Center/UCLA School of Medicine, USA.
Chloroquine and hydrocychloroquine have been evaluated in 30 noninfectious disorders and
conditions other than rheumatoid arthritis or lupus erythematosus; 12 of these have been subjected
to well-designed controlled trials. It is concluded that chloroquines are safe and effective first
line
Quoted message said:therapies for selected patients with porphyria cutanea tarda, cutaneous sarcoidosis, cutaneous
manifestations of dermatomyositis, hyperlipidemias and thromboembolic prophylaxis for patients
with antiphospholipid antibodies. Published experience with these and other diseases or
syndromes
Quoted message said:are critically reviewed.
Publication Types: Review Review, tutorial PMID: 8803913, UI: 96396809
--------------------------------------------------------------------------
--
Anyone got a scale .. ? Weighs in at .. ?
Surgery 2002 Jan;131(1):66-74
Hematin is one of the cytotoxic factors in pancreatitis-associated ascitic fluid that causes
hepatocellular injury.
Ueda T, Takeyama Y, Takase K, Hori Y, Kuroda Y, Ho HS First Department of Surgery, Kobe University
School of Medicine, Kobe, Japan.
BACKGROUND: We recently demonstrated that pancreatitis-associated ascitic fluid (PAAF) contains
cytotoxic factor(s), inducing apoptosis in hepatocytes, and that PAAF induces hepatic adenosine
triphosphate depletion, hepatocellular acidosis, and accumulation of hepatic intracellular sodium.
Because ascitic fluid and serum from patients with hemorrhagic pancreatitis contain a lot of
hematin, we aimed to test the hypothesis that hematin can induce hepatocellular injury, and then we
compared its cytotoxicity with that of PAAF.
METHODS: In vivo effects of intraperitoneal injection of hematin into the liver of healthy rats were
evaluated with in situ nick-end labeling, blood biochemical analysis, and nuclear magnetic resonance
spectroscopy. In vitro cytotoxic and apoptosis-inducing activities of hematin on rat primary culture
hepatocytes were investigated with a cellular proliferation assay kit and DNA fragmentation
enzyme-linked immunosorbent assay, respectively. Furthermore, PAAF was fractionated with Sephacryl
S-300 gel column chromatography, and cytotoxic activities of its fractions on a human hepatoma cell
line (HuH-7) were compared with those of hematin.
RESULTS: Intraperitoneal injection of hematin into healthy rats caused apoptosis in the hepatocytes
and elevated serum glutamate oxaloacetic transaminase and lactate dehydrogenase levels.
Intraperitoneal injection of hematin also caused a significant decrease in the hepatic
beta-adenosine triphosphate/inorganic phosphate ratio, severe hepatic intracellular acidosis, and a
significant increase of hepatic intracellular sodium (Na(+)) concentration, similar to the effects
of PAAF. In vitro, hematin decreased hepatocyte viability and increased the DNA fragmentation of
hepatocytes, similar to the effects of 10% PAAF. Albumin reversed the cytotoxic effects of hematin
and PAAF on HuH-7 cells nearly completely and partially, respectively. Fractionation of PAAF and
hematin by gel column chromatography revealed that the first peak of cytotoxic activity of PAAF
corresponded to that of hematin and that the cytotoxic activity was reversed by albumin nearly
completely.
CONCLUSIONS:
These results suggest that hematin is one of the cytotoxic factors in PAAF that causes
hepatocellular injury and that cellular injuries caused by hematin may be involved in the
development of multiple organ failure associated with severe acute pancreatitis.
PMID: 11812965, UI: 21672044
------------------------------------------------------------------
Who loves ya. Tom
--
Jesus Was A Vegetarian! jesuswasavegetarian.7h.comjesuswasavegetarian.7h.comOpen ↗ Man Is A Herbivore!
pages.ivillage.commanisaherbivoreOpen ↗
