http://findarticles.com/p/articles/mi_m0ISW/is_286/ai_n19170428
Lipid Replacement and antioxidant supplements to prevent membrane
oxidation and restore mitochondrial function in metabolic syndrome and
fatiguing illnesses
Townsend Letter for Doctors and Patients,
May, 2007 by Garth L. Nicolson
Abstract
One of the central defects in metabolic syndrome (MS) and its
associated diseases (type 2 diabetes, vascular inflammation,
atherosclerosis, and renal, liver, and heart disease) as well as
fatiguing illnesses is excess cellular oxidative stress mediated by
reactive oxygen and nitrogen species (ROS/RNS). Oxidative stress
affects many organ systems, including pancreatic beta cells, nerve
cells, and immune cells, and generally affects the vascular system.
Oxidative damage to mitochondrial membranes results in reduced
efficiency of the electron transport chain. Recent evidence indicates
that reduced mitochondrial function caused by ROS/RNS membrane
oxidation is related to fatigue, a complaint in MS and the major
complaint in fatiguing illnesses. Lipid Replacement Therapy
administered as a nutritional supplement with antioxidants can prevent
excess oxidative membrane damage, restore mitochondrial membrane
function, and reduce fatigue in a variety of clinical conditions.
Who loves ya.
Tom
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