Limu moui & the Immune system

Limu at Last said:

Only supplement that contains Fucoidan.

I certainly wouldn't want fucoidan if I had cancer or an undiscovered cancer.

Exp Cell Res 1998 Mar 15;239(2):301-10 Sulfated glycosaminoglycans enhance tumor cell invasion in
vitro by stimulating plasminogen activation.

Metastasizing tumor cells invade host tissues by degrading extracellular matrix constituents. We
report here that the highly sulfated glycosaminoglycans, heparin and heparan sulfate, as well as the
sulfated polysaccharide, fucoidan, significantly enhanced tumor cell invasion in vitro into fibrin,
the basement membrane extract, Matrigel, or through a basement membrane-like extracellular matrix.
The enhancement of tumor cell invasion was due to a stimulation of the proteolytic cascade of
plasminogen activation since the effect required plasminogen activation and was abolished by
inhibitors of urokinase-type plasminogen activator (uPA) or plasmin. Sulfated polysaccharides
enhanced five reactions of tumor-cell initiated plasminogen activation in a dose-dependent manner.
They amplified plasminogen activation in culture supernatants up to 70-fold by stimulating (i) pro-
uPA activation by plasmin and (ii) plasminogen activation by uPA. (iii) In addition, sulfated
polysaccharides partially protected plasmin from inactivation by alpha 2-antiplasmin. Sulfated
polysaccharides also stimulated tumor-cell associated plasminogen activation, e.g., (iv) cell
surface pro-uPA activation by plasmin and (v) plasminogen activation by cell surface uPA. These
results suggest that sulfated glycosaminoglycans liberated by tumor-cell mediated extracellular
matrix degradation in vivo might amplify pericellular plasminogen activation and locally enhance
tumor cell invasion in a positive feedback manner.