General fitness, health and nutrition · Public discussion

Lecithin / neuroprotective

Started by Doe · · Last activity · 4 posts · 608 views

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General fitness, health and nutrition
Published
4 January 2004
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20 January 2004
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Doe
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  1. Original post
    Doe
    Archived post
    #1

    Braz J Med Biol Res. 2003 Dec;36(12):1613-20. Epub 2003 Nov 17. Related Articles, Links

    Neuroprotection by flavonoids.

    Dajas F, Rivera-Megret F, Blasina F, Arredondo F, Abin-Carriquiry JA, Costa G, Echeverry C, Lafon L,
    Heizen H, Ferreira M, Morquio A.

    Departamento de Neuroquimica, Instituto de Investigaciones Biol gicas Clemente Estable, Universidade
    da Republica.

    The high morbidity, high socioeconomic costs and lack of specific treatments are key factors that
    define the relevance of brain pathology for human health and the importance of research on neuronal
    protective agents. Epidemiological studies have shown beneficial effects of flavonoids on arteriosclerosis-
    related pathology in general and neurodegeneration in particular. Flavonoids can protect the brain
    by their ability to modulate intracellular signals promoting cellular survival. Quercetin and
    structurally related flavonoids (myricetin, fisetin, luteolin) showed a marked cytoprotective
    capacity in in vitro experimental conditions in models of predominantly apoptotic death such as that
    induced by medium concentrations (200 M) of H2O2 added to PC12 cells in culture. Nevertheless,
    quercetin did not protect substantia nigra neurons in vivo from an oxidative insult (6-
    hydroxydopamine), probably due to difficulties in crossing the blood-brain barrier. On the other
    hand, treatment of permanent focal ischemia with a lecithin/quercetin preparation decreased lesion
    volume, showing that preparations that help to cross the blood-brain barrier may be critical for the
    expression of the effects of flavonoids on the brain. The hypothesis is advanced that a group of quercetin-
    related flavonoids could become lead molecules for the development of neuroprotective compounds with
    multitarget anti-ischemic effects.

    PMID: 14666245 [PubMed - in process]

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  2. Alf Christopher
    Archived post
    #2
    (doe) said:

    cellular survival. Quercetin and structurally related flavonoids (myricetin, fisetin, luteolin)
    showed a marked cytoprotective capacity in in vitro experimental conditions in models of
    predominantly apoptotic death such as that

    A study presented lately on a meeting (abstract presentation) by a group in my institute found
    significant differences in uptake of quercetin and the other compounds mentioned here in people
    eating "5 a day" compared to those eating very litte vegetables and fruits. So it is a good idea to
    eat "5 a day".

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  3. John
    Archived post
    #3

    Alf Christophersen <[email hidden]> wrote in message news:<[email hidden]>...

    Quoted message said:
    (doe) said:

    cellular survival. Quercetin and structurally related flavonoids (myricetin, fisetin, luteolin)
    showed a marked cytoprotective capacity in in vitro experimental conditions in models of
    predominantly apoptotic death such as that

    A study presented lately on a meeting (abstract presentation) by a group in my institute found
    significant differences in uptake of quercetin and the other compounds mentioned here in people
    eating "5 a day" compared to those eating very litte vegetables and fruits. So it is a good idea
    to eat "5 a day".

    But will quercetin taken orally pass the Blood Brain Barrier?. The study seems to suggest this is
    difficult.

    Thanks

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  4. Alf Christopher
    Archived post
    #4
    (John) said:

    But will quercetin taken orally pass the Blood Brain Barrier?. The study seems to suggest this is
    difficult.

    Have not checked out that, but anyway, prooxidants may do harm many other places than in brain where
    quercetin may prevent the harm done.

    Report

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