<<snip>>
we demonstrated a benefit of orally administered lactoferrin
<<snip>>
Postepy Hig Med Dosw (Online). 2007;61:283-7.Links
Immunoregulatory function of lactoferrin in immunosuppressed and
autoimmune animals.
Zimecki M, Artym J, Chodaczek G, Kocieba M, Kuryszko J, Houszka M,
Kruzel ML.
Department of Experimental Therapy,
Institute of Immunology and Experimental Therapy of the Polish Academy
of Science,
Wrocław, Poland. [email hidden]
In this article we review our recent results on the effects of
lactoferrin (LF), given orally, on the immune status of mice subjected
either to chemotherapy or immobilization stress as well as on rats
with experimentally induced autoimmune encephalomyelitis (EAE). We
demonstrated that LF accelerated reconstitution of the immune system
function after administration of a sublethal dose cyclophosphamide
(CP) and normalized the ratio of major blood cell types in that model.
Also, after application of methotrexate (MTX) LF was effective to
speed up reconstitution of the cellular and humoral immune response.
Mice treated with lethal dose of busulfan (Bu) and CP and
reconstituted with bone marrow cells (BMC) were able to quicker
develop optimal immune responses when administered LF. In addition LF
was shown to accelerate engraftment of bone marrow cells from
syngeneic donors in that model. Using immobilization stress model was
shown that LF accelerates reconstitution of the cellular and humoral
immune response. In rats with EAE lactoferrin lowered the clinical
score of the disease and diminished pathohistological changes in the
spinal cord. In summary, in a series of studies we demonstrated a
benefit of orally administered LF in immunocompromised animals.
PMID: 17507877 [PubMed - in process]
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